Evidence map›Paper›PMID 24809340›Full record

ArticlePloS one2014

Leukocyte mitochondrial DNA copy number in blood is not associated with major depressive disorder in young adults.

Ying He, Jinsong Tang, Zongchang Li, Hong Li, Yanhui Liao, Yanqing Tang, Liwen Tan, Jindong Chen, Kun Xia, Xiaogang Chen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 2 pooled it
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 57 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Circulating cell-free mitochondrial DNA, but not leukocyte mitochondrial DNA copy number, is elevated in major depressive disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018
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  12. Depressive Symptoms Predict Change in Telomere Length and Mitochondrial DNA Copy Number Across Adolescence.Journal of the American Academy of Child and Adolescent Psychiatry · 2020
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  13. Stress and Psychiatric Disorders: The Role of Mitochondria.Annual review of clinical psychology · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Ying HeInstitute of Mental Health, the Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Jinsong TangInstitute of Mental Health, the Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Zongchang LiInstitute of Genomic Medicine, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Hong LiInstitute of Mental Health, the Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Yanhui LiaoInstitute of Mental Health, the Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Yanqing TangDepartment of Psychiatry, First Affiliated Hospital, China Medical University, Shenyang, Liaoning, China.
Liwen TanInstitute of Mental Health, the Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Jindong ChenInstitute of Mental Health, the Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Kun XiaThe State Key Laboratory of Medical Genetics, Central South University, Changsha, Hunan, China.
Xiaogang ChenInstitute of Mental Health, the Second Xiangya Hospital of Central South University, Changsha, Hunan, China; The State Key Laboratory of Medical Genetics, Central South University, Changsha, Hunan, China; Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Changsha, Hunan, China; The State Key Laboratory of Medical Genetics, Central South University, Changsha, Hunan, China.
Central South University · CNSecond Xiangya Hospital of Central South University · CNChina Medical University · CNWenzhou Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMajor depressive disorder (MDD) is the leading cause of disability worldwide, and has significant genetic predisposition. Mitochondria may have a role in MDD and so mitochondrial DNA (mtDNA) has been suggested as a possible biomarker for this disease. We aimed to test whether the mtDNA copy number of peripheral blood leukocytes is related to MDD in young adults.

methodsA case-control study was conducted with 210 MDD patients and 217 healthy controls (HC). The mtDNA copy number was measured by quantitative polymerase chain reaction (qPCR) method. Depression severity was assessed by the Hamilton-17 Depression Rating Scale (HDRS-17).

resultsWe found no significant differences in mtDNA copy number between MDD patients and HC, though the power analysis showed that our sample size has enough power to detect the difference. There were also no significant correlations between mtDNA copy number and the clinical characteristics (such as age, age of onset, episodes, Hamilton Depression Rating Scale (HDRS) score and Global Assessment of Function Scale (GAF) score) in MDD patients.

conclusionOur study suggests that leukocyte mtDNA copy number is unlikely to contribute to MDD, but it doesn't mean that we can exclude the possibility of involvement of mitochondria in the disease. Further studies are required to elucidate whether mtDNA can be a biomarker of MDD.

Indexed as

Gene DosageAdolescentAdultCase-Control StudiesDNA, MitochondrialFemaleHumansLeukocytesMajor Depressive DisorderMaleYoung AdultDNA, Mitochondrial

Identifiers

PMID24809340
PMCPMC4014566
OpenAlexW1965473200

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.