Trial reportBioMed research international2014
Improvement in hemodynamic responses to metaboreflex activation after one year of training in spinal cord injured humans.
Trial report in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Exercise and aerobic capacity in individuals with spinal cord injury: A systematic review with meta-analysis and meta-regression.PLoS medicine · 2023Pooled it
- The effects of exercise training on cardiovascular responses to muscle metaboreflex activation in patients after coronary artery bypass grafting.European journal of applied physiology · 2025Article
- Article
- Muscle metaboreflex adaptations to exercise training in health and disease.European journal of applied physiology · 2021Review
- Effects of a Tailored Physical Activity Intervention on Cardiovascular Structure and Function in Individuals With Spinal Cord Injury.Neurorehabilitation and neural repair · 2021Article
- Outcomes of a Multicenter Safety and Efficacy Study of the SuitX Phoenix Powered Exoskeleton for Ambulation by Patients With Spinal Cord Injury.Frontiers in neurology · 2021Article
- Modulation of left ventricular diastolic filling during exercise in persons with cervical motor incomplete spinal cord injury.European journal of applied physiology · 2019Article
- Article
- Carotid Arterial Stiffness and Hemodynamic Responses to Acute Cycling Intervention at Different Times during 12-Week Supervised Exercise Training Period.BioMed research international · 2018Article
- Hemodynamic Responses during Enduro-Motorcycling Performance.Frontiers in physiology · 2017Article
- The Impact of Cardiovascular Diseases on Cardiovascular Regulation During Exercise in Humans: Studies on Metaboreflex Activation Elicited by the Post-exercise Muscle Ischemia Method.Current cardiology reviews · 2017Review
- Health and economic benefits of physical activity for patients with spinal cord injury.ClinicoEconomics and outcomes research : CEOR · 2016Review
- Clinical effectiveness and safety of powered exoskeleton-assisted walking in patients with spinal cord injury: systematic review with meta-analysis.Medical devices (Auckland, N.Z.) · 2016Review
- Effect of aging on hemodynamic response to metaboreflex activation.European journal of applied physiology · 2015Article
- Cardiovascular Reflexes Activity and Their Interaction during Exercise.BioMed research international · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spinal cord injured (SCI) individuals show an altered hemodynamic response to metaboreflex activation due to a reduced capacity to vasoconstrict the venous and arterial vessels below the level of the lesion. Exercise training was found to enhance circulating catecholamines and to improve cardiac preload and venous tone in response to exercise in SCI subjects. Therefore, training would result in enhanced diastolic function and capacity to vasoconstrict circulation. The aim of this study was to test the hypothesis that one year of training improves hemodynamic response to metaboreflex activation in these subjects. Nine SCI individuals were enrolled and underwent a metaboreflex activation test at the beginning of the study (T0) and after one year of training (T1). Hemodynamics were assessed by impedance cardiography and echocardiography at both T0 and T1. Results show that there was an increment in cardiac output response due to metaboreflex activity at T1 as compared to T0 (545.4 ± 683.9 mL · min(-1) versus 220.5 ± 745.4 mL · min(-1), P < 0.05). Moreover, ventricular filling rate response was higher at T1 than at T0. Similarly, end-diastolic volume response was increased after training. We concluded that a period of training can successfully improve hemodynamic response to muscle metaboreflex activation in SCI subjects.
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