ArticleBioMed research international2014
Identification of microRNA as sepsis biomarker based on miRNAs regulatory network analysis.
Article in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
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Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it, 76 citations in OpenAlex.
- The involvement of regulatory non-coding RNAs in sepsis: a systematic review.Critical care (London, England) · 2016Pooled it
- Regulatory effect of miR-142-5p on inflammatory process of sepsis by targeting CXCL8.Hereditas · 2025Article
- Harnessing Extracellular microRNAs for Diagnostics and Therapeutics in Acute Systemic Inflammation.Cells · 2024Review
- Differentiated expressed miRNAs in splenic monocyte induced by burn injury in mice.International wound journal · 2023Article
- MiR-15b-5p and PCSK9 inhibition reduces lipopolysaccharide-induced endothelial dysfunction by targeting SIRT4.Cellular & molecular biology letters · 2023Article
- A summary of the current diagnostic methods for, and exploration of the value of microRNAs as biomarkers in, sepsis-associated encephalopathy.Frontiers in neuroscience · 2023Review
- MicroRNAs combined with the TLR4/TDAG8 mRNAs and proinflammatory cytokines are biomarkers for the rapid diagnosis of sepsis.Molecular medicine reports · 2022Article
- Role of miRNA dysregulation in sepsis.Molecular medicine (Cambridge, Mass.) · 2022Review
- Influence of age and sex on microRNA response and recovery in the hippocampus following sepsis.Aging · 2022Article
- Article
- microRNA-193-3p attenuates myocardial injury of mice with sepsis via STAT3/HMGB1 axis.Journal of translational medicine · 2021Article
- Role of microRNAs As Biomarkers in Sepsis-Associated Encephalopathy.Molecular neurobiology · 2021Review
- The circulatory small non-coding RNA landscape in community-acquired pneumonia on intensive care unit admission.Journal of cellular and molecular medicine · 2021Article
- MicroRNAs: An Update of Applications in Forensic Science.Diagnostics (Basel, Switzerland) · 2020Review
- Article
- Accuracy of circulating microRNAs in diagnosis of sepsis: a systematic review and meta-analysis.Journal of intensive care · 2020Review
- Sepsis Diagnostics: Intensive Care Scoring Systems Superior to MicroRNA Biomarker Testing.Diagnostics (Basel, Switzerland) · 2020Article
- Non-coding RNAs and Exosomes: Their Role in the Pathogenesis of Sepsis.Molecular therapy. Nucleic acids · 2020Review
- microRNA-15a-5p participates in sepsis by regulating the inflammatory response of macrophages and targeting TNIP2.Experimental and therapeutic medicine · 2020Article
- Infection-induced innate antimicrobial response disorders: from signaling pathways and their modulation to selected biomarkers.Central-European journal of immunology · 2020Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sepsis is regarded as arising from an unusual systemic response to infection but the physiopathology of sepsis remains elusive. At present, sepsis is still a fatal condition with delayed diagnosis and a poor outcome. Many biomarkers have been reported in clinical application for patients with sepsis, and claimed to improve the diagnosis and treatment. Because of the difficulty in the interpreting of clinical features of sepsis, some biomarkers do not show high sensitivity and specificity. MicroRNAs (miRNAs) are small noncoding RNAs which pair the sites in mRNAs to regulate gene expression in eukaryotes. They play a key role in inflammatory response, and have been validated to be potential sepsis biomarker recently. In the present work, we apply a miRNA regulatory network based method to identify novel microRNA biomarkers associated with the early diagnosis of sepsis. By analyzing the miRNA expression profiles and the miRNA regulatory network, we obtained novel miRNAs associated with sepsis. Pathways analysis, disease ontology analysis, and protein-protein interaction network (PIN) analysis, as well as ROC curve, were exploited to testify the reliability of the predicted miRNAs. We finally identified 8 novel miRNAs which have the potential to be sepsis biomarkers.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.