ReviewTranslational medicine @ UniSa2014
Immunologic changes in frail older adults.
Review in Translational medicine @ UniSa, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 39 citations in OpenAlex.
- Interleukin 10 gene polymorphisms and frailty syndrome in elderly Mexican people: (Sadem study).Molecular genetics & genomic medicine · 2019Trial
- The Association Between Inflammatory Scores and Frailty Severity: An Exploratory Retrospective Analysis in Non-Small-Cell Lung Cancer Surgical Patients.Medical sciences (Basel, Switzerland) · 2026Article
- What strategic actions may be implemented to reach high immunisation coverage for clinically vulnerable individuals? A process for achieving regional consensus using World Cafè methods.Journal of preventive medicine and hygiene · 2025Article
- Immune profiles of pre-frail people living with HIV-1: a prospective longitudinal study.Immunity & ageing : I & A · 2024Article
- Association between Clinical Frailty Scale (CFS) and clinical presentation and outcomes in older inpatients with COVID-19.BMC geriatrics · 2023Article
- Age-Related Differences in T-Cell Subsets in a Nationally Representative Sample of People Older Than Age 55: Findings From the Health and Retirement Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- COVID-19 prevalence and mortality in longer-term care facilities.European journal of epidemiology · 2022Review
- Ageing and atherosclerosis: vascular intrinsic and extrinsic factors and potential role of IL-6.Nature reviews. Cardiology · 2021Review
- Mastication and oral sensory function in frail edentulous elderly: a case-control study.International dental journal · 2020Article
- Article
- Covid-19 Pandemic: Maximizing Future Vaccination Treatments Considering Aging and Frailty.Frontiers in medicine · 2020Article
- Meta-inflammaging at the crossroad of geroscience.Aging medicine (Milton (N.S.W)) · 2019Review
- Calcium Dyshomeostasis Alters CCL5 Signaling in Differentiated PC12 Cells.BioMed research international · 2019Article
- Impact of frailty on outcomes after discharge in older surgical patients: a prospective cohort study.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2018Observational
- Molecular pathology endpoints useful for aging studies.Ageing research reviews · 2017Review
- Workability and Muscle Strength in Patients With Seropositive Rheumatoid Arthritis: Survey Study Protocol.JMIR research protocols · 2017Article
- Preexisting Immunity, Not Frailty Phenotype, Predicts Influenza Postvaccination Titers among Older Veterans.Clinical and vaccine immunology : CVI · 2017Observational
- Article
- Article
- The Silent Epidemic - Frailty and Aging with HIV.Total patient care in HIV & HCV · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledSeveral studies have shown a heightened inflammatory state in frail older adults, marked by high serum levels of interleukin-6 and C-reactive protein and an increased number of circulating leukocytes. Activation of monocytes and macrophages, marked by increased levels of neopterin, may contribute to chronic inflammation in the frail older adult. However, the reduced mononuclear cell response to lipopolysaccharide in vitro suggests the existence of defective activation pathways within the innate immune system possibly due to desensitization. Conversely, the expansion of CD8(+) T cells, and specifically those expressing the CCR5 chemokine receptor, above and beyond the levels observed in senescence, points to the involvement of adaptive immune pathways. In line with these observations, frail older adults exhibit a reduced antibody response to pneumococcal and influenza vaccines. Collectively, these observations support the existence of a dysregulated immune system in frail older adults and highlight the need for strategies to improve its function. ABBREVIATIONS: AIDS, acquired immunodeficiency syndrome; CCL, CC-chemokine receptor ligand; CCR, CC-chemokine receptor; CHS, Cardiovascular Health Study; CMV, cytomegalovirus; GTP, guanosine trisphosphate; HAART, highly active anti-retroviral therapy; HIV, human immunodeficiency virus; IDO, indoleamine-pyrrole 2,3-dioxygenase; IL, interleukin; IFN, interferon; MACS, Multicenter AIDS Cohort Study; NH2PPP, dihydro-neopterin trisphosphate; Tc, T cytotoxic; TCR, T-cell receptor; TEMRA, T effector memory cells re-expressing CD45RA; Th, T helper; TNF, tumor necrosis factor; WHAS, Women's Health and Aging Study.
Indexed as
Identifiers
24809027PMC4012368W1831352339What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.