ArticleRare diseases (Austin, Tex.)2013
Genome-wide SNP analysis of the Systemic Capillary Leak Syndrome (Clarkson disease).
Article in Rare diseases (Austin, Tex.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 37 citations in OpenAlex.
- Monoclonal gammopathy of clinical significance: a multisystem review.Blood cancer journal · 2026Review
- Article
- Article
- Systemic capillary leak syndrome.Nature reviews. Disease primers · 2024Review
- Hypersensitive blood vessels in Clarkson disease.The Journal of clinical investigation · 2024Article
- Intrinsic endothelial hyperresponsiveness to inflammatory mediators drives acute episodes in models of Clarkson disease.The Journal of clinical investigation · 2024Article
- A ligand-independent Tie2-activating antibody reduces vascular leakage in models of Clarkson disease.Science advances · 2023Article
- Chronic systemic capillary leak syndrome with lymphatic capillaries involvement and MYOF mutation: case report and literature review.Frontiers in genetics · 2023Article
- Fatal Exacerbations of Systemic Capillary Leak Syndrome Complicating Coronavirus Disease.Emerging infectious diseases · 2021Review
- RNA sequencing of blood in coronary artery disease: involvement of regulatory T cell imbalance.BMC medical genomics · 2021Article
- ARHGEF18/p114RhoGEF Coordinates PKA/CREB Signaling and Actomyosin Remodeling to Promote Trophoblast Cell-Cell Fusion During Placenta Morphogenesis.Frontiers in cell and developmental biology · 2021Article
- Network-Based Functional Prediction Augments Genetic Association To Predict Candidate Genes for Histamine Hypersensitivity in Mice.G3 (Bethesda, Md.) · 2019Article
- Whole-Exome Sequencing of Adult and Pediatric Cohorts of the Rare Vascular Disorder Systemic Capillary Leak Syndrome.Shock (Augusta, Ga.) · 2019Article
- Myocardial oedema in an 8-year-old Chinese boy with Idiopathic systemic capillary leak syndrome.BMC pediatrics · 2019Article
- A natural mouse model reveals genetic determinants of systemic capillary leak syndrome (Clarkson disease).Communications biology · 2019Article
- Genome reorganization in different cancer types: detection of cancer specific breakpoint regions.Molecular cytogenetics · 2019Article
- Severe capillary leak syndrome with cardiac arrest triggered by influenza virus infection.BMJ case reports · 2018Article
- Association between a Single Nucleotide Polymorphism in the 3'-UTR ofDisease markers · 2018Article
- A p190BRhoGAP mutation and prolonged RhoB activation in fatal systemic capillary leak syndrome.The Journal of experimental medicine · 2017Article
- Idiopathic systemic capillary leak syndrome (Clarkson disease).The Journal of allergy and clinical immunology · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
Abstract
The Systemic Capillary Leak Syndrome (SCLS) is an extremely rare, orphan disease that resembles, and is frequently erroneously diagnosed as, systemic anaphylaxis. The disorder is characterized by repeated, transient, and seemingly unprovoked episodes of hypotensive shock and peripheral edema due to transient endothelial hyperpermeability. SCLS is often accompanied by a monoclonal gammopathy of unknown significance (MGUS). Using Affymetrix Single Nucleotide Polymorphism (SNP) microarrays, we performed the first genome-wide SNP analysis of SCLS in a cohort of 12 disease subjects and 18 controls. Exome capture sequencing was performed on genomic DNA from nine of these patients as validation for the SNP-chip discoveries and de novo data generation. We identified candidate susceptibility loci for SCLS, which included a region flanking
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.