Evidence map›Paper›PMID 24808908›Full record

ArticleFrontiers in genetics2014

Genome-wide association study and ancestral origins of the slick-hair coat in tropically adapted cattle.

Heather J Huson, Eui-Soo Kim, Robert W Godfrey, Timothy A Olson, Matthew C McClure, Chad C Chase, Rita Rizzi, Ana M P O'Brien, Curt P Van Tassell, José F Garcia and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 72 citations in OpenAlex.

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  5. Genomic patterns of selection in morphometric traits across diverse Indian cattle breeds.Mammalian genome : official journal of the International Mammalian Genome Society · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 5 countries.

Heather J HusonDepartment of Animal Science, Cornell University Ithaca, NY, USA ; Bovine Functional Genomics Laboratory, United States Department of Agriculture, Agricultural Research Services Beltsville, MD, USA.
Eui-Soo KimBovine Functional Genomics Laboratory, United States Department of Agriculture, Agricultural Research Services Beltsville, MD, USA ; Department of Animal Science, Iowa State University Ames, IA, USA.
Robert W GodfreyAgricultural Experiment Station, University of the Virgin Islands St. Croix, Virgin Islands.
Timothy A OlsonDepartment of Animal Science, University of Florida Gainsville, FL, USA.
Matthew C McClureBovine Functional Genomics Laboratory, United States Department of Agriculture, Agricultural Research Services Beltsville, MD, USA ; Irish Cattle Breeding Federation Cork, Ireland.
Chad C ChaseMeat Animal Research Center, United States Department of Agriculture, Agricultural Research Services Clay Center, NE, USA.
Rita RizziDepartment of Veterinary Medicine, Milan University Milan, Italy.
Ana M P O'BrienDivision of Livestock Sciences, BOKU University of Natural Resources and Life Sciences Vienna, Austria.
Curt P Van TassellBovine Functional Genomics Laboratory, United States Department of Agriculture, Agricultural Research Services Beltsville, MD, USA.
José F GarciaFaculdade de Medicina Veterinária de Araçatuba, UNESP - Univ Estadual Paulista Brazil.
Tad S SonstegardBovine Functional Genomics Laboratory, United States Department of Agriculture, Agricultural Research Services Beltsville, MD, USA.
Agricultural Research Service · USUnited States Department of Agriculture · USBOKU University · ATUniversidade Estadual Paulista (Unesp) · BRUniversity of Florida · USUniversity of Milan · ITUniversity of the Virgin Islands · VI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The slick hair coat (SLICK) is a dominantly inherited trait typically associated with tropically adapted cattle that are from Criollo descent through Spanish colonization of cattle into the New World. The trait is of interest relative to climate change, due to its association with improved thermo-tolerance and subsequent increased productivity. Previous studies localized the SLICK locus to a 4 cM region on chromosome (BTA) 20 and identified signatures of selection in this region derived from Senepol cattle. The current study compares three slick-haired Criollo-derived breeds including Senepol, Carora, and Romosinuano and three additional slick-haired cross-bred lineages to non-slick ancestral breeds. Genome-wide association (GWA), haplotype analysis, signatures of selection, runs of homozygosity (ROH), and identity by state (IBS) calculations were used to identify a 0.8 Mb (37.7-38.5 Mb) consensus region for the SLICK locus on BTA20 in which contains SKP2 and SPEF2 as possible candidate genes. Three specific haplotype patterns are identified in slick individuals, all with zero frequency in non-slick individuals. Admixture analysis identified common genetic patterns between the three slick breeds at the SLICK locus. Principal component analysis (PCA) and admixture results show Senepol and Romosinuano sharing a higher degree of genetic similarity to one another with a much lesser degree of similarity to Carora. Variation in GWA, haplotype analysis, and IBS calculations with accompanying population structure information supports potentially two mutations, one common to Senepol and Romosinuano and another in Carora, effecting genes contained within our refined location for the SLICK locus.

Indexed as

CaroraCriolloRomosinuanoSenepolSLICKthermo-tolerance

Identifiers

PMID24808908
PMCPMC4010767
OpenAlexW2114221415

What OpenQuestion holds

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LicenceCC BY
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.