ArticleFrontiers in computational neuroscience2014
Distributed organization of a brain microcircuit analyzed by three-dimensional modeling: the olfactory bulb.
Article in Frontiers in computational neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- The Neural Analysis Toolkit Unifies Semi-Analytical Techniques to Simplify, Understand, and Simulate Dendrites.Neuroinformatics · 2026Article
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- Multi-scale spiking network model of human cerebral cortex.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Reproducibility of biophysical in silico neuron states and spikes from event-based partial histories.PLoS computational biology · 2023Article
- NeuroML-DB: Sharing and characterizing data-driven neuroscience models described in NeuroML.PLoS computational biology · 2023Article
- A realistic morpho-anatomical connection strategy for modelling full-scale point-neuron microcircuits.Scientific reports · 2022Article
- Connectivity and dynamics in the olfactory bulb.PLoS computational biology · 2022Article
- Anatomical and Functional Connectivity at the Dendrodendritic Reciprocal Mitral Cell-Granule Cell Synapse: Impact on Recurrent and Lateral Inhibition.Frontiers in neural circuits · 2022Article
- Modernizing the NEURON Simulator for Sustainability, Portability, and Performance.Frontiers in neuroinformatics · 2022Article
- On the structural connectivity of large-scale models of brain networks at cellular level.Scientific reports · 2021Article
- Article
- Parallel odor processing by mitral and middle tufted cells in the olfactory bulb.Scientific reports · 2018Article
- Toward Rigorous Parameterization of Underconstrained Neural Network Models Through Interactive Visualization and Steering of Connectivity Generation.Frontiers in neuroinformatics · 2018Article
- Hybrid Scheme for Modeling Local Field Potentials from Point-Neuron Networks.Cerebral cortex (New York, N.Y. : 1991) · 2016Article
- Reproducibility in Computational Neuroscience Models and Simulations.IEEE transactions on bio-medical engineering · 2016Article
- Comments and General Discussion on "The Anatomical Problem Posed by Brain Complexity and Size: A Potential Solution".Frontiers in neuroanatomy · 2016Article
- Using Intrinsic Flavoprotein and NAD(P)H Imaging to Map Functional Circuitry in the Main Olfactory Bulb.PloS one · 2016Article
- Odor Experience Facilitates Sparse Representations of New Odors in a Large-Scale Olfactory Bulb Model.Frontiers in neuroanatomy · 2016Article
- Glomerular and Mitral-Granule Cell Microcircuits Coordinate Temporal and Spatial Information Processing in the Olfactory Bulb.Frontiers in computational neuroscience · 2016Article
- Rapid Feedforward Inhibition and Asynchronous Excitation Regulate Granule Cell Activity in the Mammalian Main Olfactory Bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
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4 authors.
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Abstract
The functional consequences of the laminar organization observed in cortical systems cannot be easily studied using standard experimental techniques, abstract theoretical representations, or dimensionally reduced models built from scratch. To solve this problem we have developed a full implementation of an olfactory bulb microcircuit using realistic three-dimensional (3D) inputs, cell morphologies, and network connectivity. The results provide new insights into the relations between the functional properties of individual cells and the networks in which they are embedded. To our knowledge, this is the first model of the mitral-granule cell network to include a realistic representation of the experimentally-recorded complex spatial patterns elicited in the glomerular layer (GL) by natural odor stimulation. Although the olfactory bulb, due to its organization, has unique advantages with respect to other brain systems, the method is completely general, and can be integrated with more general approaches to other systems. The model makes experimentally testable predictions on distributed processing and on the differential backpropagation of somatic action potentials in each lateral dendrite following odor learning, providing a powerful 3D framework for investigating the functions of brain microcircuits.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.