ArticleFrontiers in behavioral neuroscience2014
Context-driven activation of odor representations in the absence of olfactory stimuli in the olfactory bulb and piriform cortex.
Article in Frontiers in behavioral neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Hippocampal communication with the anterior olfactory nucleus is necessary for context-dependent odor memory.Behavioral neuroscience · 2026Article
- Article
- Reinforced Odor Representations in the Anterior Olfactory Nucleus Can Serve as Memory Traces for Conspecifics.eNeuro · 2025Article
- Article
- Olfactory threat extinction in the piriform cortex: An age-dependent employment of NMDA receptor-dependent long-term depression.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Olfactory neurogenesis and its role in fear memory modulation.Frontiers in behavioral neuroscience · 2023Review
- Article
- Connectivity and dynamics in the olfactory bulb.PLoS computational biology · 2022Article
- Basolateral amygdala to posterior piriform cortex connectivity ensures precision in learned odor threat.Scientific reports · 2021Article
- Cortical feedback and gating in odor discrimination and generalization.PLoS computational biology · 2021Article
- Context-dependent odor learning requires the anterior olfactory nucleus.Behavioral neuroscience · 2020Article
- Rapid online learning and robust recall in a neuromorphic olfactory circuit.Nature machine intelligence · 2020Article
- Top-down inputs drive neuronal network rewiring and context-enhanced sensory processing in olfaction.PLoS computational biology · 2019Article
- Hippocampal projections to the anterior olfactory nucleus differentially convey spatiotemporal information during episodic odour memory.Nature communications · 2018Article
- Preprocessing of emotional visual information in the human piriform cortex.Scientific reports · 2017Article
- Redefining the Role of Limbic Areas in Cortical Processing.Trends in cognitive sciences · 2016Review
- Internal Cholinergic Regulation of Learning and Recall in a Model of Olfactory Processing.Frontiers in cellular neuroscience · 2016Article
- Olfactory memory networks: from emotional learning to social behaviors.Frontiers in behavioral neuroscience · 2015Article
- Learning modulation of odor representations: new findings from Arc-indexed networks.Frontiers in cellular neuroscience · 2014Review
- Article
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6 authors.
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Abstract
Sensory neural activity is highly context dependent and shaped by experience and expectation. In the olfactory bulb (OB), the first cerebral relay of olfactory processing, responses to odorants are shaped by previous experiences including contextual information thanks to strong feedback connections. In the present experiment, mice were conditioned to associate an odorant with a visual context and were then exposed to the visual context alone. We found that the visual context alone elicited exploration of the odor port similar to that elicited by the stimulus when it was initially presented. In the OB, the visual context alone elicited a neural activation pattern, assessed by mapping the expression of the immediate early gene zif268 (egr-1) that was highly similar to that evoked by the conditioned odorant, but not other odorants. This OB activation was processed by olfactory network as it was transmitted to the piriform cortex. Interestingly, a novel context abolished neural and behavioral responses. In addition, the neural representation in response to the context was dependent on top-down inputs, suggesting that context-dependent representation is initiated in cortex. Modeling of the experimental data suggests that odor representations are stored in cortical networks, reactivated by the context and activate bulbar representations. Activation of the OB and the associated behavioral response in the absence of physical stimulus showed that mice are capable of internal representations of sensory stimuli. The similarity of activation patterns induced by imaged and the corresponding physical stimulus, triggered only by the relevant context provides evidence for an odor-specific internal representation.
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