Evidence map›Paper›PMID 24808762›Full record

ArticleCancer cell international2014

The association between hypoxia-inducible factor-1 α gene G1790A polymorphism and cancer risk: a meta-analysis of 28 case-control studies.

Yuqiao Zhou, Lin Lin, Yun Wang, Xin Jin, Xin Zhao, Dongjuan Liu, Ting Hu, Lu Jiang, Hongxia Dan, Xin Zeng and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer cell international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Review
  6. Sequence and functional characterization of hypoxia-inducible factors, HIF1α, HIF2αa, and HIF3α, from the estuarine fish,American journal of physiology. Regulatory, integrative and comparative physiology · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yuqiao Zhou *State Key Laboratory of Oral Diseases, West China College of Stomatology, Sichuan University, No.14 the 3rd Section of Renmin South Road, Chengdu, Sichuan 610041, China.
Lin Lin *State Key Laboratory of Oral Diseases, West China College of Stomatology, Sichuan University, No.14 the 3rd Section of Renmin South Road, Chengdu, Sichuan 610041, China.
Yun WangState Key Laboratory of Oral Diseases, West China College of Stomatology, Sichuan University, No.14 the 3rd Section of Renmin South Road, Chengdu, Sichuan 610041, China.
Xin JinState Key Laboratory of Oral Diseases, West China College of Stomatology, Sichuan University, No.14 the 3rd Section of Renmin South Road, Chengdu, Sichuan 610041, China.
Xin ZhaoState Key Laboratory of Oral Diseases, West China College of Stomatology, Sichuan University, No.14 the 3rd Section of Renmin South Road, Chengdu, Sichuan 610041, China.
Dongjuan LiuState Key Laboratory of Oral Diseases, West China College of Stomatology, Sichuan University, No.14 the 3rd Section of Renmin South Road, Chengdu, Sichuan 610041, China.
Ting HuState Key Laboratory of Oral Diseases, West China College of Stomatology, Sichuan University, No.14 the 3rd Section of Renmin South Road, Chengdu, Sichuan 610041, China.
Lu JiangState Key Laboratory of Oral Diseases, West China College of Stomatology, Sichuan University, No.14 the 3rd Section of Renmin South Road, Chengdu, Sichuan 610041, China.
Hongxia DanState Key Laboratory of Oral Diseases, West China College of Stomatology, Sichuan University, No.14 the 3rd Section of Renmin South Road, Chengdu, Sichuan 610041, China.
Xin ZengState Key Laboratory of Oral Diseases, West China College of Stomatology, Sichuan University, No.14 the 3rd Section of Renmin South Road, Chengdu, Sichuan 610041, China.
Jing LiState Key Laboratory of Oral Diseases, West China College of Stomatology, Sichuan University, No.14 the 3rd Section of Renmin South Road, Chengdu, Sichuan 610041, China.
Jiayi WangDepartment of Oral Radiology, West China College of Stomatology, Sichuan University, No.14 the 3rd Section of Renmin South Road, Chengdu, Sichuan 610041, China.
Qianming ChenState Key Laboratory of Oral Diseases, West China College of Stomatology, Sichuan University, No.14 the 3rd Section of Renmin South Road, Chengdu, Sichuan 610041, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeHypoxia-inducible factor-1 (HIF-1) is a key transcription factor that regulates the cellular adaptation to hypoxia. HIF-1α gene single nucleotide polymorphisms (SNPs) are implicated to be associated with cancer risks. However, results from the published studies remained inconclusive. The aim of this study is to investigate the relationship of HIF-1α gene G1790A polymorphism with cancer using meta-analysis.

methodsA comprehensive search in Pubmed, EMBASE and China National Knowledge Infrastructure (CNKI) was conducted to identify all publications on the association between this polymorphism and cancer until December 13, 2013. Odds ratios (OR) with 95% confidence intervals (95% CI) were used to evaluate the strength of this association. Association between lymph node metastasis and G1790A was also investigated.

resultsA total of 5985 cases and 6809 controls in 28 case-control studies were included in this meta-analysis. The A allele of HIF-1α gene G1790A polymorphism was found to be significantly associated with increased cancer risk in four genetic models: AA + AG vs. GG (dominant model OR = 1.85, 95% CI = 1.27-2.69), AA vs. AG + GG (recessive model OR = 5.69, 95% CI = 3.87-8.37), AA vs. GG (homozygote comparison OR = 6.63, 95% CI = 4.49-9.79), and AG vs. GG (heterozygote comparison OR = 2.39, 95% CI = 1.53-3.75). This variant was also significantly associated with higher risks of pancreatic cancer, head and neck cancer, lung cancer and renal cell carcinoma. However, the A allele of G1790A was not significantly associated with increased lymph node metastasis in the dominant model by overall meta-analysis.

conclusionsOur meta-analysis suggests that the substitution of G with A of HIF-1α gene G1790A polymorphism is a risk factor of cancer, especially for pancreatic cancer, lung cancer, renal cell carcinoma and head and neck cancer. The association is significant in Asian, Caucasian population and public based control subgroups. However, it's not associated with risk of lymph node metastasis.

Indexed as

CancerHIF-1αMeta-analysisPolymorphism

Identifiers

PMID24808762
PMCPMC4012095

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.