ArticleJournal of basic and clinical pharmacy2013
Antidiabetic and antihyperlipidemic effects of an ethanolic extract of the whole plant of Tridax procumbens (Linn.) in streptozotocin-induced diabetic rats.
Article in Journal of basic and clinical pharmacy, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 61 citations in OpenAlex.
- The antioxidant, antidiabetic, and antihyperlipidemic effects of the polyphenolic extract from Salvia blancoana subsp. mesatlantica on induced diabetes in rats.Bioresources and bioprocessing · 2024Article
- Green Synthesis, Characterizations of Zinc Oxide Nanoparticles from Aqueous Leaf Extract ofMaterials (Basel, Switzerland) · 2022Article
- Article
- High anti-inflammatory and antidiabetic activities ofJournal of diabetes and metabolic disorders · 2021Article
- Larvicidal Evaluation againstTheScientificWorldJournal · 2021Article
- Antihyperglycemic and Antihyperlipidemic Effects of Aqueous Extracts ofFrontiers in pharmacology · 2018Article
- A preliminary report on oral glucose tolerance and antinociceptive activity tests conducted with methanol extract of Xanthosoma violaceum aerial parts.BMC complementary and alternative medicine · 2014Article
- Antidiabetic activity of polyherbal formulation in streptozotocin - nicotinamide induced diabetic wistar rats.Journal of traditional and complementary medicine · 2014Article
- Ameliorative Effect of Curcumin on Olanzapine-induced Obesity in Sprague-Dawley Rats.Pharmacognosy researchArticle
- Evaluation of Antidiabetic and Antihyperlipidemic Effects of Hydroalcoholic Extract of Leaves of Ocimum tenuiflorum (Lamiaceae) and Prediction of Biological Activity of its Phytoconstituents.Pharmacognosy researchArticle
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3 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
objectiveTo study the antidiabetic and antihyperlipidemic effects of an ethanolic extract of the whole plant of Tridax procumbens (Asteraceae) in streptozotocin-induced diabetic rats. MATERIALS AND
methodsThe whole plant of T. procumbens was collected in different regions of Madurai districts, Tamil Nadu. The air dried whole plant of T. procumbens was extracted with ethanol (95%) in a Soxhlet apparatus for 72 h. Diabetes was induced in male Wistar rats by streptozotocin (50 mg/jk, i.p.) and nicotinamide (120 mg/kg, i.p) injection. The dry mass of the extract was used for preliminary phytochemical and pharmacological analysis. Diabetic rats were treated with glibenclamide (0.25 mg/kg, p.o.) or T. procumbens extract (250 and 500 mg/k, p.o.) for 21 consecutive days. The blood samples were collected at regular intervals to access hypoglycemic effect of an ethanolic extract of the whole plant of T. procumbens. At the end of the experiment, serum lipid profile and liver enzymes levels were analyzed for all the experimental animals and compared with diabetic control.
resultsThe preliminary phytochemical analysis of an ethanolic extract of the whole plant of T. procumbens indicated the presence of alkaloids, tannins, flavonoids, saponins, and phenolic compounds. The ethanolic extract of the whole plant of T. procumbens at 250 and 500 mg/kg has significant antidiabetic and antihyperlipidemic activities. The diabetic control animals exhibited a significant decrease in body weight compared with control animals. T. procumbens inhibited streptozotocin-induced weight loss and significantly alter the lipid levels.
conclusionThe ethanolic extract of the whole plant of T. procumbens showed significant antidiabetic and antihyperlipidemic activities against streptozotocin-induced diabetes in rats.
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