Evidence map›Paper›PMID 24808491›Full record

SynthesisThe American journal of clinical nutrition2014

Nut consumption in relation to cardiovascular disease risk and type 2 diabetes: a systematic review and meta-analysis of prospective studies.

Donghao Zhou, Haibing Yu, Fang He, Kathleen Heather Reilly, Jingling Zhang, Shuangshuang Li, Tao Zhang, Baozhen Wang, Yuanlin Ding, Bo Xi

Registry-linked trialAbstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in The American journal of clinical nutrition, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03224533 (Association Between Walnut Consumption and Diabetes Risk in NHANES May be Gender Sex Specific), which is not on this map. Cited by 59 papers, 15 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 15 pooled it
11.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03224533 completednot on this mapstarted 2015, after this paper: background citation

Association Between Walnut Consumption and Diabetes Risk in NHANES May be Gender Sex Specific

TypeobservationalSponsorUniversity of California, Los AngelesRan2015 to 2017Enrolled34,121ConditionsDiabetes MellitusArmsDiabetes Outcome
3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 15 syntheses or guidelines pooled it, 143 citations in OpenAlex.

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  7. Effects of Hazelnut Consumption on Cardiometabolic Risk Factors and Acceptance: A Systematic Review.International journal of environmental research and public health · 2022
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  13. Nut consumption for the primary prevention of cardiovascular disease.The Cochrane database of systematic reviews · 2015
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Donghao ZhouFrom the Department of Endocrinology, Linyi People's Hospital, Linyi, China (DZ and JZ); the School of Public Health, Southern Medical University, Guangzhou, China (HY); the Institute of Medical Systems Biology, School of Public Health, Guangdong Medical College, Dongguan, China (HY and YD); the Department of Internal Medicine, Linyi People's Hospital, Linyi, China (FH); Independent Consultant, New York (KHR); the Department of Epidemiology and Health Statistics, School of Public Health, Shandong University, Jinan, China (SL, TZ, and BX); and the Department of Nutrition and Food Hygiene (BW), School of Public Health, Shandong University, Jinan, China.
Haibing YuFrom the Department of Endocrinology, Linyi People's Hospital, Linyi, China (DZ and JZ); the School of Public Health, Southern Medical University, Guangzhou, China (HY); the Institute of Medical Systems Biology, School of Public Health, Guangdong Medical College, Dongguan, China (HY and YD); the Department of Internal Medicine, Linyi People's Hospital, Linyi, China (FH); Independent Consultant, New York (KHR); the Department of Epidemiology and Health Statistics, School of Public Health, Shandong University, Jinan, China (SL, TZ, and BX); and the Department of Nutrition and Food Hygiene (BW), School of Public Health, Shandong University, Jinan, China.
Fang HeFrom the Department of Endocrinology, Linyi People's Hospital, Linyi, China (DZ and JZ); the School of Public Health, Southern Medical University, Guangzhou, China (HY); the Institute of Medical Systems Biology, School of Public Health, Guangdong Medical College, Dongguan, China (HY and YD); the Department of Internal Medicine, Linyi People's Hospital, Linyi, China (FH); Independent Consultant, New York (KHR); the Department of Epidemiology and Health Statistics, School of Public Health, Shandong University, Jinan, China (SL, TZ, and BX); and the Department of Nutrition and Food Hygiene (BW), School of Public Health, Shandong University, Jinan, China.
Kathleen Heather ReillyFrom the Department of Endocrinology, Linyi People's Hospital, Linyi, China (DZ and JZ); the School of Public Health, Southern Medical University, Guangzhou, China (HY); the Institute of Medical Systems Biology, School of Public Health, Guangdong Medical College, Dongguan, China (HY and YD); the Department of Internal Medicine, Linyi People's Hospital, Linyi, China (FH); Independent Consultant, New York (KHR); the Department of Epidemiology and Health Statistics, School of Public Health, Shandong University, Jinan, China (SL, TZ, and BX); and the Department of Nutrition and Food Hygiene (BW), School of Public Health, Shandong University, Jinan, China.
Jingling ZhangFrom the Department of Endocrinology, Linyi People's Hospital, Linyi, China (DZ and JZ); the School of Public Health, Southern Medical University, Guangzhou, China (HY); the Institute of Medical Systems Biology, School of Public Health, Guangdong Medical College, Dongguan, China (HY and YD); the Department of Internal Medicine, Linyi People's Hospital, Linyi, China (FH); Independent Consultant, New York (KHR); the Department of Epidemiology and Health Statistics, School of Public Health, Shandong University, Jinan, China (SL, TZ, and BX); and the Department of Nutrition and Food Hygiene (BW), School of Public Health, Shandong University, Jinan, China.
Shuangshuang LiFrom the Department of Endocrinology, Linyi People's Hospital, Linyi, China (DZ and JZ); the School of Public Health, Southern Medical University, Guangzhou, China (HY); the Institute of Medical Systems Biology, School of Public Health, Guangdong Medical College, Dongguan, China (HY and YD); the Department of Internal Medicine, Linyi People's Hospital, Linyi, China (FH); Independent Consultant, New York (KHR); the Department of Epidemiology and Health Statistics, School of Public Health, Shandong University, Jinan, China (SL, TZ, and BX); and the Department of Nutrition and Food Hygiene (BW), School of Public Health, Shandong University, Jinan, China.
Tao ZhangFrom the Department of Endocrinology, Linyi People's Hospital, Linyi, China (DZ and JZ); the School of Public Health, Southern Medical University, Guangzhou, China (HY); the Institute of Medical Systems Biology, School of Public Health, Guangdong Medical College, Dongguan, China (HY and YD); the Department of Internal Medicine, Linyi People's Hospital, Linyi, China (FH); Independent Consultant, New York (KHR); the Department of Epidemiology and Health Statistics, School of Public Health, Shandong University, Jinan, China (SL, TZ, and BX); and the Department of Nutrition and Food Hygiene (BW), School of Public Health, Shandong University, Jinan, China.
Baozhen WangFrom the Department of Endocrinology, Linyi People's Hospital, Linyi, China (DZ and JZ); the School of Public Health, Southern Medical University, Guangzhou, China (HY); the Institute of Medical Systems Biology, School of Public Health, Guangdong Medical College, Dongguan, China (HY and YD); the Department of Internal Medicine, Linyi People's Hospital, Linyi, China (FH); Independent Consultant, New York (KHR); the Department of Epidemiology and Health Statistics, School of Public Health, Shandong University, Jinan, China (SL, TZ, and BX); and the Department of Nutrition and Food Hygiene (BW), School of Public Health, Shandong University, Jinan, China.
Yuanlin DingFrom the Department of Endocrinology, Linyi People's Hospital, Linyi, China (DZ and JZ); the School of Public Health, Southern Medical University, Guangzhou, China (HY); the Institute of Medical Systems Biology, School of Public Health, Guangdong Medical College, Dongguan, China (HY and YD); the Department of Internal Medicine, Linyi People's Hospital, Linyi, China (FH); Independent Consultant, New York (KHR); the Department of Epidemiology and Health Statistics, School of Public Health, Shandong University, Jinan, China (SL, TZ, and BX); and the Department of Nutrition and Food Hygiene (BW), School of Public Health, Shandong University, Jinan, China.
Bo XiFrom the Department of Endocrinology, Linyi People's Hospital, Linyi, China (DZ and JZ); the School of Public Health, Southern Medical University, Guangzhou, China (HY); the Institute of Medical Systems Biology, School of Public Health, Guangdong Medical College, Dongguan, China (HY and YD); the Department of Internal Medicine, Linyi People's Hospital, Linyi, China (FH); Independent Consultant, New York (KHR); the Department of Epidemiology and Health Statistics, School of Public Health, Shandong University, Jinan, China (SL, TZ, and BX); and the Department of Nutrition and Food Hygiene (BW), School of Public Health, Shandong University, Jinan, China.
Linyi People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMany prospective cohort studies have investigated the association between nut consumption and risk of coronary artery disease (CAD), stroke, hypertension, and type 2 diabetes (T2D). However, results have been inconsistent.

objectiveWe aimed to investigate the association between nut consumption and risk of CAD, stroke, hypertension, and T2D.

designPubMed and EMBASE databases were searched up to October 2013. All prospective cohort studies of nut consumption and risk of CAD, stroke, hypertension, and T2D were included. Summary RRs with 95% CIs were estimated by using a fixed- or random-effects model.

resultsA total of 23 prospective studies (9 studies for CAD, 4 studies for stroke, 4 studies for hypertension, and 6 studies for T2D) from 19 publications were included in the meta-analysis. There were 179,885 participants and 7236 CAD cases, 182,730 participants and 5669 stroke cases, 40,102 participants and 12,814 hypertension cases, and 342,213 participants and 14,400 T2D cases. The consumption of each 1 serving of nuts/d was significantly associated with incident CAD (RR: 0.81; 95% CI: 0.72, 0.91; P < 0.001) and hypertension (RR: 0.66; 95% CI: 0.44, 1.00; P = 0.049). However, there was no association between the consumption of each 1 serving of nuts/d and risk of stroke (RR: 0.90; 95% CI: 0.71, 1.14) or T2D (RR: 0.80; 95% CI: 0.57, 1.14).

conclusionsA higher consumption of nuts was associated with reduced risk of CAD and hypertension but not stroke or T2D. Large randomized controlled trials are warranted to confirm the observed associations.

Indexed as

DietNutsCardiovascular DiseasesDatabases, FactualDiabetes Mellitus, Type 2HumansRisk FactorsRisk Reduction Behavior

Identifiers

PMID24808491
OpenAlexW2163875227

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.