ReviewBritish medical bulletin1989
Structural and functional analysis of insulin-like growth factors.
Review in British medical bulletin, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04298684 (Efficacy of Metformin Versus Sitagliptin on Benign Thyroid Nodules Size in Type 2 Diabetes), which is not on this map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Efficacy of Metformin Versus Sitagliptin on Benign Thyroid Nodules Size in Type 2 Diabetes: a 2-years Prospective Multicentric Study
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.
- Metformin and thyroid carcinoma incidence and prognosis: A systematic review and meta-analysis.PloS one · 2022Pooled it
- AMPK-mTORC1 pathway mediates hepatic IGFBP-1 phosphorylation in glucose deprivation: a potential molecular mechanism of hypoglycemia-induced impaired fetal growth.Journal of molecular endocrinology · 2024Article
- Review
- Abnormal Glucose Metabolism Parameters and the Aggressiveness of Differentiated Thyroid Carcinoma: A Hospital-Based Cross-Section Study in China.Frontiers in endocrinology · 2022Observational
- Hyperphosphorylation of fetal liver IGFBP-1 precedes slowing of fetal growth in nutrient-restricted baboons and may be a mechanism underlying IUGR.American journal of physiology. Endocrinology and metabolism · 2020Article
- "Is there any association between insulin resistance and thyroid cancer? : A case control study".Endocrine · 2014Article
- Diabetes and thyroid cancer risk: literature review.Experimental diabetes research · 2012Review
- Diabetes and thyroid cancer risk in the National Institutes of Health-AARP Diet and Health Study.Thyroid : official journal of the American Thyroid Association · 2011Article
- Insulin and insulin resistance.The Clinical biochemist. Reviews · 2005Article
- Zinc alters the kinetics of IGF-II binding to cell surface receptors and binding proteins.Endocrine · 2003Article
- Nutrition, hormones, and breast cancer: is insulin the missing link?Cancer causes & control : CCC · 1996Review
- Augmentation of synthesis of plasminogen activator inhibitor type 1 by insulin and insulin-like growth factor type I: implications for vascular disease in hyperinsulinemic states.Proceedings of the National Academy of Sciences of the United States of America · 1991Article
- The gene encoding rat insulinlike growth factor-binding protein 1 is rapidly and highly induced in regenerating liver.Molecular and cellular biology · 1991Article
- Molecular biology of the insulin-like growth factors. Relevance to nervous system function.Molecular neurobiologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The insulin and insulin-like growth factor family of peptides are proteins with similar structural characteristics whose functions have diverged during evolution. Recent studies have provided a great deal of information regarding structural characteristics of these peptides, the structures of the genes that control their biosynthesis, and determination of their receptor structures. Initially these factors were believed to function as classical hormones and the endocrine regulation of their blood concentrations was studied intensively. More recently several cell types have been shown to secrete these peptides and the autocrine and paracrine regulation of insulin-like growth factor secretion by cells and tissues has received extensive characterization. Following secretion into interstitial fluids the IGF's associate with high affinity, soluble binding proteins. These proteins are capable of modulating receptor binding and growth factor biological activity. The structure of these proteins and the variables that control their secretion are currently being determined. In spite of this information significant gaps in our knowledge exist regarding the mechanisms by which these peptides stimulate replication.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.