ReviewIntegrative and comparative biology2014
Mechanisms underlying epigenetic regulation in Arabidopsis thaliana.
Review in Integrative and comparative biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 16 citations in OpenAlex.
- Systematic genome-wide and expression analysis of RNA-directed DNA methylation pathway genes in grapes predicts their involvement in multiple biological processes.Frontiers in plant science · 2022Article
- Ambient Temperature-Responsive Mechanisms Coordinate Regulation of Flowering Time.International journal of molecular sciences · 2018Review
- Mechanism of evolution by genetic assimilation : Equivalence and independence of genetic mutation and epigenetic modulation in phenotypic expression.Biophysical reviews · 2018Review
- Epigenetics in comparative biology: why we should pay attention.Integrative and comparative biology · 2014Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
In plants, epigenetic regulation mediates both the proper development of the plant and responses to environmental cues. Changes in epigenetic states employ DNA methylation, histone modification, and regulatory RNAs. In Arabidopsis thaliana, DNA methylation as a repressive mark is often associated with constitutively silenced loci, such as repetitive sequences, transposons, and heterochromatin. These sequences regularly give rise to small interfering RNAs, which direct DNA methylation through the RNA-directed DNA methylation (RdDM) pathway. For example, FWA locus is silenced in sporophytes and enriched with DNA methylation. Its methylated state is stable and passes to the next generation. This is an example of meiotically inherited epigenetic states. There are also epigenetic changes that can be inherited mitotically and are subsequently erased in the next generation. In this review, we use the vernalization-mediated epigenetic silencing of FLOWERING LOCUS C (FLC) as an example for this type of mitotically stable epigenetic state. Here, we discuss mechanisms of epigenetic changes that can result in meiotically or mitotically stable states with an emphasis on FWA and FLC as two examples.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.