SynthesisBMJ clinical evidence2014
Retinal detachment.
Synthesis in BMJ clinical evidence, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06541574 (Prevention of ProliFerative Vitreoretinopathy with Intravitreal MethotreXate in Primary Retinal DEtachment Repair), which is not on this map. Cited by 53 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prevention of ProliFerative Vitreoretinopathy with Intravitreal MethotreXate in Primary Retinal DEtachment Repair (FIXER) Trial
Who cites it
53 citing papers in PubMed, 3 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- Combined 5-Fluorouracil and Low Molecular Weight Heparin for the Prevention of Postoperative Proliferative Vitreoretinopathy in Patients With Retinal Detachment: A Meta-Analysis.Frontiers in medicine · 2021Pooled it
- Pars plana vitrectomy versus scleral buckling for repairing simple rhegmatogenous retinal detachments.The Cochrane database of systematic reviews · 2019Pooled it
- Pneumatic retinopexy versus scleral buckle for repairing simple rhegmatogenous retinal detachments.The Cochrane database of systematic reviews · 2015Pooled it
- ERDES: A Benchmark Video Dataset for Retinal Detachment and Macular Status Classification in Ocular Ultrasound.Scientific data · 2026Article
- Aptamer-Based Delivery Systems for VEGF and NGF Modulation in Ocular Therapies.Advanced healthcare materials · 2026Review
- Shaping the future of myopia: artificial intelligence for vitreoretinal complications of high and pathologic myopia.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Review
- Review
- Incidence and risk factors for retinal detachment after cataract surgery: a comparison between trainee and experienced surgeons.International journal of retina and vitreous · 2026Article
- A Systematic Approach to Managing Acute Visual Loss: A Comprehensive Review of Literature.Cureus · 2026Review
- Grading retinal displacement after retinal detachment repair: a prospective study linking displacement grade and visual outcome.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025Article
- Bone morphogenetic proteins (BMPs) at the forefront of ocular diseases and therapeutics.Eye and vision (London, England) · 2025Review
- A review of rhegmatogenous retinal detachment: past, present and future.Wiener medizinische Wochenschrift (1946) · 2025Review
- Automated Detection of Retinal Detachment Using Deep Learning-Based Segmentation on Ocular Ultrasonography Images.Translational vision science & technology · 2025Article
- Climate and Rhegmatogenous Retinal Detachment: A Retrospective and Multi-Site Study in the High Desert of the United States.Clinical ophthalmology (Auckland, N.Z.) · 2025Article
- Article
- Anatomic and functional prognosis of vitreoretinal surgery in rhegmatogenous retinal detachment associated with intraocular inflammation.Eye (London, England) · 2024Article
- Review
- Vitrectomy versus scleral buckle for retinal detachment without posterior vitreous detachment.Scientific reports · 2024Article
- Anti-inflammatory potential of simvastatin and amfenac in ARPE-19 cells; insights in preventing re-detachment and proliferative vitreoretinopathy after rhegmatogenous retinal detachment surgery.International ophthalmology · 2024Article
- Baseline imaging characteristics and early structural changes in macula on rhegmatogenous retinal detachment.Scientific reports · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionRhegmatogenous retinal detachment (RRD) is the most common form of retinal detachment, where a retinal 'break' allows the ingress of fluid from the vitreous cavity to the subretinal space, resulting in retinal separation. It occurs in about 1 in 10,000 people a year. METHODS AND OUTCOMES: We conducted a systematic review and aimed to answer the following clinical questions: What are the effects of different surgical interventions in people with rhegmatogenous retinal detachment? What are the effects of interventions to treat proliferative vitreoretinopathy occurring as a complication of retinal detachment or previous treatment for retinal detachment? We searched: Medline, Embase, The Cochrane Library, and other important databases up to September 2013 (Clinical Evidence reviews are updated periodically; please check our website for the most up-to-date version of this review). We included harms alerts from relevant organisations such as the US Food and Drug Administration (FDA) and the UK Medicines and Healthcare products Regulatory Agency (MHRA).
resultsWe found 14 studies that met our inclusion criteria. We performed a GRADE evaluation of the quality of evidence for interventions.
conclusionsIn this systematic review, we present information relating to the effectiveness and safety of the following interventions: corticosteroids, daunorubicin, fluorouracil plus low molecular weight heparin, pneumatic retinopexy, scleral buckling, short-acting or long-acting gas tamponade, silicone oil tamponade, and vitrectomy.
Indexed as
Identifiers
24807890PMC3940167W4298347007What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.