ArticleAmerican journal of reproductive immunology (New York, N.Y. : 1989)2014
Longitudinal profiling of inflammatory cytokines and C-reactive protein during uncomplicated and preterm pregnancy.
Article in American journal of reproductive immunology (New York, N.Y. : 1989), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 98 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
98 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- A systematic review of genetic association studies on the susceptibility of preterm birth in Asia.Molecular genetics and genomics : MGG · 2025Pooled it
- Is there a maternal blood biomarker that can predict spontaneous preterm birth prior to labour onset? A systematic review.PloS one · 2022Pooled it
- Associations of Serum Inflammatory Biomarkers During Pregnancy With Placental Pathology and Placental Gene Expression at Delivery.American journal of reproductive immunology (New York, N.Y. : 1989) · 2025Trial
- Negative correlation between serial changes in the reticulocyte number and C-reactive protein level in dogs with delayed reticulocytosis.The Journal of veterinary medical science · 2026Article
- Inflammation, sleep, and trait mindfulness in pregnancy.Sleep health · 2026Article
- Noninvasive PPROM risk stratification with explainable AI using routine antenatal CRP and albumin.NPJ digital medicine · 2026Article
- Complement and neutrophils are actively involved at the cervicovaginal interface in cases of adverse microbial composition, cervical shortening and spontaneous preterm birth.NPJ biofilms and microbiomes · 2026Article
- Associations between prenatal per- and polyfluoroalkyl substances (PFAS) and repeated measures of bioactive lipids during pregnancy in the LIFECODES cohort.The Science of the total environment · 2026Article
- Article
- A cross-sectional examination of immune adaptations during pregnancy in the ECHO Cohort.Frontiers in immunology · 2026Article
- Association between organic micropollutants in tap water and human exposure and birth outcomes: Implications for environmental health in northern Puerto Rico.Journal of hazardous materials · 2025Article
- Maternal telomere length and oxidative stress in pregnancy: cross-sectional analysis with an exploratory examination of systemic inflammation.BMC pregnancy and childbirth · 2025Article
- The single-cell immune profile throughout gestation and its potential value for identifying women at risk for spontaneous preterm birth.European journal of obstetrics & gynecology and reproductive biology: X · 2025Review
- Predicting preterm birth using machine learning methods.Scientific reports · 2025Article
- Estimating the associations between women's maltreatment in childhood and inflammatory biomarker levels prior to and during pregnancy.PloS one · 2025Article
- Inflammatory markers in pregnancy - identifying drivers in four large cohorts.Frontiers in immunology · 2025Article
- Prenatal exposure to per- and polyfluoroalkyl substances (PFAS) and their influence on inflammatory biomarkers in pregnancy: Findings from the LIFECODES cohort.Environment international · 2024Article
- Investigating Menstruation and Adverse Pregnancy Outcomes: Oxymoron or New Frontier? A Narrative Review.Journal of clinical medicine · 2024Review
- Impact of previous pregnancy and BMI on cellular and serum immune activity from early to late pregnancy.Scientific reports · 2024Article
- Stress and anxiety during pregnancy and length of gestation: a federated study using data from five Canadian and European birth cohorts.European journal of epidemiology · 2024Article
38 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
problemPrevious studies have investigated the utility of inflammation markers as predictors of preterm birth, but none have compared trends in levels between uncomplicated and preterm pregnancy. METHOD OF STUDY: We explored longitudinal changes in plasma cytokines, including IL-1β, IL-6, IL-10, and TNF-α, as well as C-reactive protein in pregnant women from a nested case-control study.
resultsIL-6 was associated with increased odds of spontaneous preterm birth, defined by presentation of spontaneous preterm labor and/or preterm premature rupture of the membranes. Associations were strongest later in pregnancy. IL-10 was associated with increased odds of placentally mediated preterm birth, defined by presentation with preeclampsia or intrauterine growth restriction, and odds ratios were also highest near the end of pregnancy.
conclusionMaternal inflammation markers were associated with increased risk of preterm birth, and relationships differed by etiology of preterm delivery and gestational age at sample collection.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.