ArticleBiophysical journal2014
Variable cell morphology approach for individual-based modeling of microbial communities.
Article in Biophysical journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- A minimal mechanically consistent model of smoothly dividing disk-shaped cells.NPJ systems biology and applications · 2026Article
- Genetically homogeneous sector morphologies emerge from anisotropic colony growth.Physical review. E · 2026Article
- Dissecting the physics of bacterial biofilms with agent-based simulations.Current opinion in solid state & materials science · 2025Article
- Time of first contact determines cooperator success in a three-member microbial consortium.ISME communications · 2025Article
- An off-lattice discrete model to characterise filamentous yeast colony morphology.PLoS computational biology · 2024Article
- Optogenetic Control of Bacterial Cell-Cell Adhesion Dynamics: Unraveling the Influence on Biofilm Architecture and Functionality.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Is it selfish to be filamentous in biofilms? Individual-based modeling links microbial growth strategies with morphology using the new and modular iDynoMiCS 2.0.PLoS computational biology · 2024Article
- Distinct types of multicellular aggregates in Pseudomonas aeruginosa liquid cultures.NPJ biofilms and microbiomes · 2023Article
- Anomalous diffusion of nanoparticles in the spatially heterogeneous biofilm environment.iScience · 2023Article
- Incorporating Cellular Stochasticity in Solid-Fluid Mixture Biofilm Models.Entropy (Basel, Switzerland) · 2020Article
- Article
- Bacterial growth: a statistical physicist's guide.Reports on progress in physics. Physical Society (Great Britain) · 2019Review
- Continuum and discrete approach in modeling biofilm development and structure: a review.Journal of mathematical biology · 2018Review
- Modeling de novo granulation of anaerobic sludge.BMC systems biology · 2017Article
- Cell morphology drives spatial patterning in microbial communities.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Modeling of Mesoscale Variability in Biofilm Shear Behavior.PloS one · 2016Article
- On the genealogy of tissue engineering and regenerative medicine.Tissue engineering. Part B, Reviews · 2015Review
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Authors and funding
4 authors.
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Abstract
An individual-based, mass-spring modeling framework has been developed to investigate the effect of cell properties on the structure of biofilms and microbial aggregates through Lagrangian modeling. Key features that distinguish this model are variable cell morphology described by a collection of particles connected by springs and a mechanical representation of deformable intracellular, intercellular, and cell-substratum links. A first case study describes the colony formation of a rod-shaped species on a planar substratum. This case shows the importance of mechanical interactions in a community of growing and dividing rod-shaped cells (i.e., bacilli). Cell-substratum links promote formation of mounds as opposed to single-layer biofilms, whereas filial links affect the roundness of the biofilm. A second case study describes the formation of flocs and development of external filaments in a mixed-culture activated sludge community. It is shown by modeling that distinct cell-cell links, microbial morphology, and growth kinetics can lead to excessive filamentous proliferation and interfloc bridging, possible causes for detrimental sludge bulking. This methodology has been extended to more advanced microbial morphologies such as filament branching and proves to be a very powerful tool in determining how fundamental controlling mechanisms determine diverse microbial colony architectures.
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Registered trials
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