ArticleJournal of the Royal Society, Interface2014
Synchrotron imaging reveals bone healing and remodelling strategies in extinct and extant vertebrates.
Article in Journal of the Royal Society, Interface, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Injuries in deep time: interpreting competitive behaviours in extinct reptiles via palaeopathology.Biological reviews of the Cambridge Philosophical Society · 2026Review
- In situ analysis of vascular structures in fractured Tyrannosaurus rex rib.Scientific reports · 2025Article
- Article
- Independent Evidence for the Preservation of Endogenous Bone Biochemistry in a Specimen ofBiology · 2023Article
- Histological and chemical diagnosis of a combat lesion in Triceratops.Scientific reports · 2022Article
- Seasonal calibration of the end-cretaceous Chicxulub impact event.Scientific reports · 2021Article
- Visualizing mineralization processes and fossil anatomy using synchronous synchrotron X-ray fluorescence and X-ray diffraction mapping.Journal of the Royal Society, Interface · 2020Article
- Investigation of a bone lesion in a gorgonopsian (Synapsida) from the Permian of Zambia and periosteal reactions in fossil non-mammalian tetrapods.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
- Pain in dinosaurs: what is the evidence?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Review
- Pheomelanin pigment remnants mapped in fossils of an extinct mammal.Nature communications · 2019Article
- Article
- A new synchrotron rapid-scanning X-ray fluorescence (SRS-XRF) imaging station at SSRL beamline 6-2.Journal of synchrotron radiation · 2018Article
- Simulation enabled search for explanatory mechanisms of the fracture healing process.PLoS computational biology · 2018Article
- Incremental distribution of strontium and zinc in great ape and fossil hominin cementum using synchrotron X-ray fluorescence mapping.Journal of the Royal Society, Interface · 2018Article
- Elemental characterisation of melanin in feathers via synchrotron X-ray imaging and absorption spectroscopy.Scientific reports · 2016Article
- Vascularised endosteal bone tissue in armoured sauropod dinosaurs.Scientific reports · 2016Article
- BMP signalling in skeletal development, disease and repair.Nature reviews. Endocrinology · 2016Review
- Article
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Current understanding of bone healing and remodelling strategies in vertebrates has traditionally relied on morphological observations through the histological analysis of thin sections. However, chemical analysis may also be used in such interpretations, as different elements are known to be absorbed and used by bone for different physiological purposes such as growth and healing. These chemical signatures are beyond the detection limit of most laboratory-based analytical techniques (e.g. scanning electron microscopy). However, synchrotron rapid scanning-X-ray fluorescence (SRS-XRF) is an elemental mapping technique that uniquely combines high sensitivity (ppm), excellent sample resolution (20-100 µm) and the ability to scan large specimens (decimetre scale) approximately 3000 times faster than other mapping techniques. Here, we use SRS-XRF combined with microfocus elemental mapping (2-20 µm) to determine the distribution and concentration of trace elements within pathological and normal bone of both extant and extinct archosaurs (Cathartes aura and Allosaurus fragilis). Results reveal discrete chemical inventories within different bone tissue types and preservation modes. Chemical inventories also revealed detail of histological features not observable in thin section, including fine structures within the interface between pathological and normal bone as well as woven texture within pathological tissue.
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