ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
Scale-free bursting in human cortex following hypoxia at birth.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Symmetry breaking and avalanche shapes in modular neural networks.Frontiers in computational neuroscience · 2026Article
- Ephaptic coupling and power fluctuations in depression.bioRxiv : the preprint server for biology · 2025Article
- Maturation of Neuronal Activity in the Human Cortex Exhibits Robust Spatial Gradients across the Birth Transition.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Bridge, Reverse Bridge, and Their Control.Entropy (Basel, Switzerland) · 2025Article
- Electroencephalography and optical neuromonitoring predict short-term outcomes in neonates undergoing therapeutic hypothermia for hypoxic-ischemic encephalopathy.Scientific reports · 2025Article
- Hierarchies of description enable understanding of cognitive phenomena in terms of neuron activity.Cognitive processing · 2024Review
- Early EEG-burst sharpness and 2-year disability in extremely preterm infants.Pediatric research · 2024Article
- Mechanisms underlying pathological cortical bursts during metabolic depletion.Nature communications · 2023Article
- Sexual reproductive health service utilization and associated factors among undergraduate students of Addis Ababa University in Ethiopia.Journal of health, population, and nutrition · 2023Article
- Early brain activity: Translations between bedside and laboratory.Progress in neurobiology · 2022Review
- Quasicriticality explains variability of human neural dynamics across life span.Frontiers in computational neuroscience · 2022Article
- Prognostic value of neonatal EEG following therapeutic hypothermia in survivors of hypoxic-ischemic encephalopathy.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2021Article
- Automated cot-side tracking of functional brain age in preterm infants.Annals of clinical and translational neurology · 2020Article
- Stability of neuronal avalanches and long-range temporal correlations during the first year of life in human infants.Brain structure & function · 2020Article
- Why Brain Criticality Is Clinically Relevant: A Scoping Review.Frontiers in neural circuits · 2020Article
- Article
- Breakdown of Scaling and Friction Weakening in Intermittent Granular Flow.Scientific reports · 2019Article
- The scale-invariant, temporal profile of neuronal avalanches in relation to cortical γ-oscillations.Scientific reports · 2019Article
- Avalanches and criticality in self-organized nanoscale networks.Science advances · 2019Article
- Neuronal avalanches and time-frequency representations in stimulus-evoked activity.Scientific reports · 2019Article
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5 authors.
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Abstract
The human brain is fragile in the face of oxygen deprivation. Even a brief interruption of metabolic supply at birth challenges an otherwise healthy neonatal cortex, leading to a cascade of homeostatic responses. During recovery from hypoxia, cortical activity exhibits a period of highly irregular electrical fluctuations known as burst suppression. Here we show that these bursts have fractal properties, with power-law scaling of burst sizes across a remarkable 5 orders of magnitude and a scale-free relationship between burst sizes and durations. Although burst waveforms vary greatly, their average shape converges to a simple form that is asymmetric at long time scales. Using a simple computational model, we argue that this asymmetry reflects activity-dependent changes in the excitatory-inhibitory balance of cortical neurons. Bursts become more symmetric following the resumption of normal activity, with a corresponding reorganization of burst scaling relationships. These findings place burst suppression in the broad class of scale-free physical processes termed crackling noise and suggest that the resumption of healthy activity reflects a fundamental reorganization in the relationship between neuronal activity and its underlying metabolic constraints.
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