Evidence map›Paper›PMID 24806593›Full record

ArticleACS applied materials & interfaces2014

Nanopore biosensor for label-free and real-time detection of anthrax lethal factor.

Liang Wang, Yujing Han, Shuo Zhou, Guihua Wang, Xiyun Guan

Open access · bronzeAbstract read
In one paragraph

Article in ACS applied materials & interfaces, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 43 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Probe-assisted detection of FeBiosensors & bioelectronics · 2024
    Article
  6. Article
  7. Article
  8. Article
  9. Salt-Mediated Nanopore Detection of ADAM-17.ACS applied bio materials · 2019
    Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Label-Free Detection of DNA Mutations by Nanopore Analysis.ACS applied materials & interfaces · 2018
    Article
  15. Membrane protein-based biosensors.Journal of the Royal Society, Interface · 2018
    Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Liang WangDepartment of Biological and Chemical Sciences, Illinois Institute of Technology , 3101 South Dearborn Street, Chicago, Illinois 60616, United States.
Yujing Han
Shuo Zhou
Guihua Wang
Xiyun Guan
Illinois Institute of Technology · US

Funding

Label-Free Nanopore Biosensor for Rapid, Ultrasensitive, and Multiplex Detection of Protease ActivitiesR15GM110632 · NIGMS · ILLINOIS INSTITUTE OF TECHNOLOGY · PI GUAN, XIYUN · 2014 to 2017
$746k
NIGMS NIH HHS 1R15GM110632NIGMS NIH HHS R15 GM110632
6 · The paper itself

Abstract

We report a label-free real-time nanopore sensing method for the detection of anthrax lethal factor, a component of the anthrax toxin, by using a complementary single-stranded DNA as a molecular probe. The method is rapid and sensitive: sub-nanomolar concentrations of the target anthrax lethal factor DNA could be detected in ∼1 min. Further, our method is selective, which can differentiate the target DNA from other single-stranded DNA molecules at the single-base resolution. This sequence-specific detection approach should find useful application in the development of nanopore sensors for the detection of other pathogens.

Indexed as

Biosensing TechniquesNanoporesAntigens, BacterialBacillus anthracisBacterial ToxinsBase SequenceDNA, BacterialDNA, Single-StrandedHemolysin ProteinsNucleic Acid Hybridizationanthrax toxinAntigens, BacterialBacterial ToxinsDNA, BacterialDNA, Single-StrandedHemolysin Proteins

Identifiers

PMID24806593
PMCPMC4039345
OpenAlexW2333606639

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.