ArticleHead and neck pathology2015
Prognostic utility of Hyams histological grading and Kadish-Morita staging systems for esthesioneuroblastoma outcomes.
Article in Head and neck pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 2 of them syntheses that pooled it.
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Who cites it
50 citing papers in PubMed, 2 syntheses or guidelines pooled it, 141 citations in OpenAlex.
- Consolidating the Hyams grading system in esthesioneuroblastoma - an individual participant data meta-analysis.Journal of neuro-oncology · 2021Pooled it
- Hyams grading as a predictor of metastasis and overall survival in esthesioneuroblastoma: a meta-analysis.International forum of allergy & rhinology · 2019Pooled it
- Long-term analysis of multimodality treatment outcomes and prognosis of esthesioneuroblastomas: a single center results of 138 patients.Radiation oncology (London, England) · 2020Trial
- DNA Virus Detection in Olfactory Neuroblastomas Using Targeted Enrichment NGS.Neuropathology : official journal of the Japanese Society of Neuropathology · 2026Article
- Does Hyams Grade Impact Outcomes in Olfactory Neuroblastoma?The Laryngoscope · 2025Article
- Hyams Grade and Ki-67 as Predictive Factors for Primary Treatment Failure in Olfactory Neuroblastoma.The Laryngoscope · 2025Article
- When Appearances Deceive: From Poorly Differentiated Carcinoma to unveiling Olfactory Neuroblastoma in a Highly Vascular Sinonasal tumor.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2025Article
- Refinement of Hyams Grading Criteria for Olfactory Neuroblastoma in an Endoscopic Sinus Surgery Predominant Cohort with Extended Follow-up: Worth the Effort?Head and neck pathology · 2025Article
- The 100 most-cited papers on esthesioneuroblastoma: a bibliometric analysis.Annals of medicine and surgery (2012) · 2025Review
- Article
- Endoscopy-assisted medial canthus incision for olfactory neuroblastoma: a case report.World journal of surgical oncology · 2024Article
- A Case of Olfactory Neuroblastoma Developing Bilateral Retropharyngeal Lymph Node Metastasis 14-years After Skull Base Surgery.The Kobe journal of medical sciences · 2024Article
- Update on olfactory neuroblastoma.Virchows Archiv : an international journal of pathology · 2024Review
- Ectopic Olfactory Neuroblastoma: Systematic Review of a Rare Clinical Entity among Sinonasal Tumors.Journal of neurological surgery. Part B, Skull base · 2024Article
- Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma.Cancer research communications · 2023Article
- Proceedings of the 2023 North American Society of Head and Neck Pathology Companion Meeting, New Orleans, LA, March 12, 2023: Navigating New Developments in High Grade Sinonasal Neuroendocrine and Neuroectodermal Neoplasms.Head and neck pathology · 2023Review
- Molecular Evidence for Olfactory Neuroblastoma as a Tumor of Malignant Globose Basal Cells.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2023Article
- Article
- Treatment outcomes and prognostic factors of esthesioneuroblastoma-a retrospective study from South India.Ecancermedicalscience · 2023Article
- Dramatic response to targeted therapy in an aggressive olfactory neuroblastoma: illustrative case.Journal of neurosurgery. Case lessons · 2022Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Esthesioneuroblastoma (ENB) is derived from the specialized olfactory neuroepithelium. Hyams grading and Kadish staging have been used to prognosticate and to guide treatment decisions. In this study, we sought to validate the prognostic utility of these systems in a large ENB cohort. We retrospectively analyzed the records of patients with ENB who had been evaluated and treated at our institution. The association of grade and stage with prognostic outcome was assessed; the Kaplan-Meier estimator was used to generate 5-year OS and DFS curves. Out of 124 cases we identified, 121 were assessed for grading and 109 for staging. Review of the tissue samples revealed that 62 % of tumors were low grade (I/II) and 21 % were high grade (III/IV); 17 % of tumors were metastasis. The OS rate was 75 % at 5 years. The DFS was 60 % at 5 years. The OS was significantly worse for metastatic ENB (low-grade ENB vs metastatic ENB p = 0.01598); the DFS was significantly worse for high grade versus low grade ENB. Of the 109 cases that had been staged, 16 % were stage A, 33 % stage B, 43 % stage C, and 8 % stage D. In the A, B, and C groups, there were no significant differences between recurrence, distant metastasis, or 5-year survival rates. Statistical significance was not reached with the T, N, M and overall staging system. Age cutoff of 65 years reliably predicted OS. High grade of ENB was significantly associated with poor outcome, while advanced stage was not associated with poor outcome in this large cohort. Grading should certainly be considered in prognostication and treatment decisions for ENB.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.