ArticleEuropean journal of nuclear medicine and molecular imaging2014
Extrastriatal binding of [¹²³I]FP-CIT in the thalamus and pons: gender and age dependencies assessed in a European multicentre database of healthy controls.
Article in European journal of nuclear medicine and molecular imaging, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Trial
- Dose-dependent effects of the selective serotonin reuptake inhibitor citalopram: A combined SPECT and phMRI study.Journal of psychopharmacology (Oxford, England) · 2019Trial
- N-Acetyl Cysteine May Support Dopamine Neurons in Parkinson's Disease: Preliminary Clinical and Cell Line Data.PloS one · 2016Trial
- Methylphenidate effects on brain activity as a function of SLC6A3 genotype and striatal dopamine transporter availability.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Trial
- Insular monoaminergic deficits in prodromal α-synucleinopathies.Annals of clinical and translational neurology · 2024Article
- Whole-brain dopamine transporter binding pattern predicts survival in multiple system atrophy.Translational neurodegeneration · 2024Article
- Association between body mass index (BMI) and [European journal of hybrid imaging · 2023Article
- Serotonin transporter is negatively associated with body mass index after glucose loading in humans.Brain imaging and behavior · 2022Article
- Explainable AI to improve acceptance of convolutional neural networks for automatic classification of dopamine transporter SPECT in the diagnosis of clinically uncertain parkinsonian syndromes.European journal of nuclear medicine and molecular imaging · 2022Article
- Data-driven identification of diagnostically useful extrastriatal signal in dopamine transporter SPECT using explainable AI.Scientific reports · 2021Article
- In vivo human molecular neuroimaging of dopaminergic vulnerability along the Alzheimer's disease phases.Alzheimer's research & therapy · 2021Article
- Impact of age and sex correction on the diagnostic performance of dopamine transporter SPECT.European journal of nuclear medicine and molecular imaging · 2021Article
- Neuropsychiatric symptoms and striatal monoamine availability in early Parkinson's disease without dementia.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021Article
- Preserved ExtrastriatalMolecular imaging and biology · 2020Article
- Impact of the size of the normal database on the performance of the specific binding ratio in dopamine transporter SPECT.EJNMMI physics · 2020Article
- ExtrastriatalBMC neurology · 2020Article
- Low thalamic monoamine transporter availability is related to excessive daytime sleepiness in early Parkinson's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020Article
- Sex and the dopaminergic system: Insights from addiction studies.Handbook of clinical neurology · 2020Review
- Automatic classification of dopamine transporter SPECT: deep convolutional neural networks can be trained to be robust with respect to variable image characteristics.European journal of nuclear medicine and molecular imaging · 2019Article
- Extrastriatal dopaminergic and serotonergic pathways in Parkinson's disease and in dementia with Lewy bodies: aEuropean journal of nuclear medicine and molecular imaging · 2019Article
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22 authors.
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Abstract
purposeApart from binding to the dopamine transporter (DAT), [(123)I]FP-CIT shows moderate affinity for the serotonin transporter (SERT), allowing imaging of both monoamine transporters in a single imaging session in different brain areas. The aim of this study was to systematically evaluate extrastriatal binding (predominantly due to SERT) and its age and gender dependencies in a large cohort of healthy controls.
methodsSPECT data from 103 healthy controls with well-defined criteria of normality acquired at 13 different imaging centres were analysed for extrastriatal binding using volumes of interest analysis for the thalamus and the pons. Data were examined for gender and age effects as well as for potential influence of striatal DAT radiotracer binding.
resultsThalamic binding was significantly higher than pons binding. Partial correlations showed an influence of putaminal DAT binding on measured binding in the thalamus but not on the pons. Data showed high interindividual variation in extrastriatal binding. Significant gender effects with 31 % higher binding in women than in men were observed in the thalamus, but not in the pons. An age dependency with a decline per decade (±standard error) of 8.2 ± 1.3 % for the thalamus and 6.8 ± 2.9 % for the pons was shown.
conclusionThe potential to evaluate extrastriatal predominant SERT binding in addition to the striatal DAT in a single imaging session was shown using a large database of [(123)I]FP-CIT scans in healthy controls. For both the thalamus and the pons, an age-related decline in radiotracer binding was observed. Gender effects were demonstrated for binding in the thalamus only. As a potential clinical application, the data could be used as a reference to estimate SERT occupancy in addition to nigrostriatal integrity when using [(123)I]FP-CIT for DAT imaging in patients treated with selective serotonin reuptake inhibitors.
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