Evidence map›Paper›PMID 24805070›Full record

ReviewExperimental neurology2014

Where attention falls: Increased risk of falls from the converging impact of cortical cholinergic and midbrain dopamine loss on striatal function.

Martin Sarter, Roger L Albin, Aaron Kucinski, Cindy Lustig

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Experimental neurology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
74citing papers in PubMed, 2 pooled it
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

74 citing papers in PubMed, 2 syntheses or guidelines pooled it, 115 citations in OpenAlex.

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  13. Cognitive Impact of β-Amyloid Load in the Rapid Eye Movement Sleep Behavior Disorder-Lewy Body Disease Continuum.Movement disorders : official journal of the Movement Disorder Society · 2024
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14 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Martin SarterDepartment of Psychology, Neuroscience Program, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: msarter@umich.edu.
Roger L AlbinNeurology Service and Geriatric Research, Education and Clinical Center, Veterans Administration Ann Arbor Healthcare System, University of Michigan, Ann Arbor, MI 48109, USA; Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA.
Aaron KucinskiDepartment of Psychology, Neuroscience Program, University of Michigan, Ann Arbor, MI 48109, USA.
Cindy LustigDepartment of Psychology, Neuroscience Program, University of Michigan, Ann Arbor, MI 48109, USA.
University of Michigan–Ann Arbor · USVA Ann Arbor Healthcare System · US

Funding

Public Outreach and Education CoreP50NS091856 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ALBIN, ROGER L · 2014 to 2019
$10.1M
Variation in Motivational Properties of Reward Cues: Implications for AddictionP01DA031656 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ROBINSON, TERRY E. · 2012 to 2016
$6.3M
Choline transporter capacity limits motivated behavior on mice, rats, and humansR01MH086530 · NIMH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SARTER, MARTIN F · 2010 to 2014
$1.9M
NIDA NIH HHS 1P01 DA031656NIDA NIH HHS P01 DA031656NIMH NIH HHS 1R01MH086530NIMH NIH HHS R01 MH086530NINDS NIH HHS P50 NS091856
6 · The paper itself

Abstract

Falls are a major source of hospitalization, long-term institutionalization, and death in older adults and patients with Parkinson's disease (PD). Limited attentional resources are a major risk factor for falls. In this review, we specify cognitive-behavioral mechanisms that produce falls and map these mechanisms onto a model of multi-system degeneration. Results from PET studies in PD fallers and findings from a recently developed animal model support the hypothesis that falls result from interactions between loss of basal forebrain cholinergic projections to the cortex and striatal dopamine loss. Striatal dopamine loss produces inefficient, low-vigor gait, posture control, and movement. Cortical cholinergic deafferentation impairs a wide range of attentional processes, including monitoring of gait, posture and complex movements. Cholinergic cell loss reveals the full impact of striatal dopamine loss on motor performance, reflecting loss of compensatory attentional supervision of movement. Dysregulation of dorsomedial striatal circuitry is an essential, albeit not exclusive, mediator of falls in this dual-system model. Because cholinergic neuromodulatory activity influences cortical circuitry primarily via stimulation of α4β2* nicotinic acetylcholine receptors, and because agonists at these receptors are known to benefit attentional processes in animals and humans, treating PD fallers with such agonists, as an adjunct to dopaminergic treatment, is predicted to reduce falls. Falls are an informative behavioral endpoint to study attentional-motor integration by striatal circuitry.

Indexed as

Accidental FallsAttentionAcetylcholineAnimalsCerebral CortexCorpus StriatumDopamineHumansMesencephalonParkinson DiseaseAcetylcholineDopamineAcetylcholineBasal forebrainDopamineFallsStriatum

Identifiers

PMID24805070
PMCPMC4348073
OpenAlexW1973427834

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.