ArticleAIDS (London, England)2014
HIV sexual transmission risk among serodiscordant couples: assessing the effects of combining prevention strategies.
Article in AIDS (London, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 3 syntheses or guidelines pooled it, 66 citations in OpenAlex.
- The Association Between Different Levels of Suppressed Viral Load and the Risk of Sexual Transmission of HIV Among Serodiscordant Couples on Antiretroviral Therapy: A Systematic Review.AIDS and behavior · 2026Pooled it
- Changing Knowledge and Attitudes Towards HIV Treatment-as-Prevention and "Undetectable = Untransmittable": A Systematic Review.AIDS and behavior · 2021Pooled it
- Trends in Sexual Behavior Among Men Who have Sex with Men (MSM) in High-Income Countries, 1990-2013: A Systematic Review.AIDS and behavior · 2017Pooled it
- Social Influence and Uptake of Couples HIV Testing and Counselling in KwaZulu-Natal, South Africa.AIDS and behavior · 2022Trial
- Pre-Human Immunodeficiency Virus (HIV) α4β7hi CD4+ T Cells and HIV Risk Among Heterosexual Individuals in Africa.The Journal of infectious diseases · 2025Article
- The impact of Undetectable=Untransmittable and viral suppression on condomless sex among mixed HIV-status couples in Canada.PloS one · 2025Article
- Article
- Modeling the impact of different PrEP targeting strategies combined with a clinic-based HIV-1 nucleic acid testing intervention in Kenya.Epidemics · 2023Article
- Sexual behaviours and correlates of condom use among HIV-discordant couples from eastern China: a cross-sectional study.BMJ open · 2023Article
- "It comes altogether as one:" perceptions of analytical treatment interruptions and partner protections among racial, ethnic, sex and gender diverse HIV serodifferent couples in the United States.BMC public health · 2022Article
- HIV-serodifferent couples' perspectives and practices regarding HIV prevention strategies: A mixed methods study.PLOS global public health · 2022Article
- Perceived efficacy of HIV treatment-as-prevention among university students in Johannesburg, South Africa.Sexually transmitted infections · 2021Article
- Article
- "It Had a Lot of Cultural Stuff in It": HIV-Serodiscordant African American Couples' Experiences of a Culturally Congruent Sexual Health Intervention.Ethnicity & disease · 2020Article
- Repeated semen exposure decreases cervicovaginal SIVmac251 infection in rhesus macaques.Nature communications · 2019Article
- Strategies used by gay male HIV serodiscordant couples to reduce the risk of HIV transmission from anal intercourse in three countries.Journal of the International AIDS Society · 2019Article
- Time spent with HIV viral load above 1500 copies/ml among patients in HIV care, 2000-2014.AIDS (London, England) · 2018Observational
- Intervention Packages to Reduce the Impact of HIV and HCV Infections Among People Who Inject Drugs in Eastern Europe and Central Asia: A Modeling and Cost-effectiveness Study.Open forum infectious diseases · 2018Article
- Examination of HIV infection through heterosexual contact with partners who are known to be HIV infected in the United States.AIDS (London, England) · 2017Article
- Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe number of strategies to prevent HIV transmission has increased following trials evaluating antiretroviral therapy (ART), preexposure prophylaxis (PrEP) and male circumcision. Serodiscordant couples need guidance on the effects of these strategies alone, and in combination with each other, on HIV transmission.
methodsWe estimated the sexual risk of HIV transmission over 1-year and 10-year periods among male-male and male-female serodiscordant couples. We assumed the following reductions in transmission: 80% from consistent condom use; 54% from circumcision in the negative male partner of a heterosexual couple; 73% from circumcision in the negative partner of a male-male couple; 71% from PrEP in heterosexual couples; 44% from PrEP in male-male couples; and 96% from ART use by the HIV-infected partner.
findingsFor couples using any single prevention strategy, a substantial cumulative risk of HIV transmission remained. For a male-female couple using only condoms, estimated risk over 10 years was 11%; for a male-male couple using only condoms, estimated risk was 76%. ART use by the HIV-infected partner was the most effective single strategy in reducing risk; among male-male couples, adding consistent condom use was necessary to keep the 10-year risk below 10%.
conclusionFocusing on 1-year and longer term transmission probabilities gives couples a better understanding of risk than those illustrated by data for a single sexual act. Long-term transmission probabilities to the negative partner in serodiscordant couples can be high, though these can be substantially reduced with the strategic use of preventive methods, especially those that include ART.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.