Evidence map›Paper›PMID 24804806›Full record

ArticleThe British journal of nutrition2014

The association between Mediterranean Diet Score and glucokinase regulatory protein gene variation on the markers of cardiometabolic risk: an analysis in the European Prospective Investigation into Cancer (EPIC)-Norfolk study.

Mercedes Sotos-Prieto, Robert Luben, Kay-Tee Khaw, Nicholas J Wareham, Nita G Forouhi

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The British journal of nutrition, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Mercedes Sotos-PrietoGenetic and Molecular Epidemiology Unit, Department of Preventive Medicine and Public Health, School of Medicine, University of Valencia, Valencia, Spain. CIBER Fisiopatología de la Obesidad y Nutrición,Valencia,Spain.
Robert LubenDepartment of Public Health and Primary Care,University of Cambridge,Cambridge,UK.
Kay-Tee KhawDepartment of Public Health and Primary Care,University of Cambridge,Cambridge,UK.
Nicholas J WarehamMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine,Institute of Metabolic Science, Cambridge Biomedical Campus,CambridgeCB2 0QQ,UK.
Nita G ForouhiMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine,Institute of Metabolic Science, Cambridge Biomedical Campus,CambridgeCB2 0QQ,UK.
University of Cambridge · GBMRC Epidemiology Unit · GBSpanish National Centre for Cardiovascular Research · ES

Funding

Cancer Research UK 14136Medical Research Council G0401527Medical Research Council G1000143Medical Research Council MC_U106179471Medical Research Council MC_UP_A100_1003Medical Research Council MC_UU_12015/1Medical Research Council MC_UU_12015/5
6 · The paper itself

Abstract

Consumption of a Mediterranean diet (MD) and genetic variation in the glucokinase regulatory protein (GCKR) gene have been reported to be associated with TAG and glucose metabolism. It is uncertain whether there is any interaction between these factors. Therefore, the aims of the present study were to test the association of adherence to a MD and rs780094 (G>A) SNP in the GCKR gene with the markers of cardiometabolic risk, and to investigate the interaction between genetic variation and MD adherence. We studied 20 986 individuals from the European Prospective Investigation into Cancer (EPIC)-Norfolk study. The relative Mediterranean Diet Score (rMED: range 0-18) was used to assess MD adherence. Linear regression was used to estimate the association between the rMED, genotype and cardiometabolic continuous traits, adjusting for potential confounders. In adjusted analyses, we observed independent associations of MD adherence and genotype with cardiometabolic risk, with the highest risk group (AA genotype; lowest rMED) having higher concentrations of TAG, total cholesterol and apoB (12·5, 2·3 and 3·1%, respectively) v. those at the lowest risk (GG genotype; highest rMED). However, the associations of MD adherence with metabolic markers did not differ by genotype, with no significant gene-diet interactions for lipids or for glycated Hb. In conclusion, we found independent associations of the rMED and of the GCKR genotype with cardiometabolic profile, but found no evidence of interaction between them.

Indexed as

Diet, MediterraneanPatient CompliancePolymorphism, Single NucleotideAdaptor Proteins, Signal TransducingAdultAgedBiomarkersCardiovascular DiseasesCohort StudiesCross-Sectional StudiesDiabetes Mellitus, Type 2EnglandFemaleGene-Environment InteractionGenetic Association StudiesGlycated HemoglobinAdaptor Proteins, Signal TransducingBiomarkersGCKR protein, humanGlycated Hemoglobinhemoglobin A1c protein, humanLipids

Identifiers

PMID24804806
PMCPMC4174631
OpenAlexW2008454126

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.