Evidence map›Paper›PMID 24804797›Full record

ReviewHuman vaccines & immunotherapeutics2014

Vaccines against invasive Salmonella disease: current status and future directions.

Calman A MacLennan, Laura B Martin, Francesca Micoli

Abstract readReview
In one paragraph

Review in Human vaccines & immunotherapeutics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 126 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
126citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

126 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Vaccines for preventing typhoid fever.The Cochrane database of systematic reviews · 2018
    Pooled it
  3. Article
  4. SeaB is a conservedInfection and immunity · 2026
    Article
  5. Article
  6. Article
  7. HarnessingMaterials today. Bio · 2025
    Article
  8. Poultry Food Assess Risk Model forFoods (Basel, Switzerland) · 2025
    Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Evaluation of theFrontiers in bioengineering and biotechnology · 2025
    Article
  14. SHASI-ML: a machine learning-based approach for immunogenicity prediction inFrontiers in cellular and infection microbiology · 2025
    Article
  15. Foodborne Infections andVaccines · 2024
    Review
  16. Immunopeptidomics ofBiology · 2024
    Article
  17. Review
  18. Article
  19. Review
  20. Frontiers in cellular and infection microbiology · 2024
    Article

66 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Calman A MacLennanNovartis Vaccines Institute for Global Health; Siena, Italy; Medical Research Council Centre for Immune Regulation and Clinical Immunology Service; Institute of Biomedical Research, School of Immunity and Infection; College of Medicine and Dental Sciences; University of Birmingham; Birmingham, UK.
Laura B MartinNovartis Vaccines Institute for Global Health; Siena, Italy.
Francesca MicoliNovartis Vaccines Institute for Global Health; Siena, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Though primarily enteric pathogens, Salmonellae are responsible for a considerable yet under-appreciated global burden of invasive disease. In South and South-East Asia, this manifests as enteric fever caused by serovars Typhi and Paratyphi A. In sub-Saharan Africa, a similar disease burden results from invasive nontyphoidal Salmonellae, principally serovars Typhimurium and Enteritidis. The existing Ty21a live-attenuated and Vi capsular polysaccharide vaccines target S. Typhi and are not effective in young children where the burden of invasive Salmonella disease is highest. After years of lack of investment in new Salmonella vaccines, recent times have seen increased interest in the area led by emerging-market manufacturers, global health vaccine institutes and academic partners. New glycoconjugate vaccines against S. Typhi are becoming available with similar vaccines against other invasive serovars in development. With other new vaccines under investigation, including live-attenuated, protein-based and GMMA vaccines, now is an exciting time for the Salmonella vaccine field.

Indexed as

Africa South of the SaharaAsiaDrug DiscoveryHumansSalmonella InfectionsSalmonella VaccinesSalmonella Vaccinesentericglobal healthglycoconjugateGMMAnontyphoidalSalmonellatyphoidvaccines

Identifiers

PMID24804797
PMCPMC4185946

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.