Tying up PGE2 with albumin to relieve immunosuppression in cirrhosis.

Vicente Arroyo, Richard Moreau

Abstract readComment

In one paragraph

Article in Nature medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it

0cells of the map it votes in

8citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

Baseline (modified) Glasgow prognostic score as a predictor of therapeutic response to immune checkpoint inhibitors in solid tumors: A systematic review and meta‑analysis.Oncology letters · 2025
Article
The Impact of Liver Failure on the Immune System.International journal of molecular sciences · 2024
Review
Incidence and Outcomes of Brucella Endocarditis in a High-Prevalence Area: A Single-Center Study.Journal of epidemiology and global health · 2024
Article
The Glasgow Prognostic Score Predicts Outcomes of Pembrolizumab or Atezolizumab Monotherapy in Patients with Pretreated Non-Small Cell Lung Cancer.Oncology · 2023
Article
Danger signals in liver injury and restoration of homeostasis.Journal of hepatology · 2020
Review
Role of ascitic prostaglandin E2 in diagnosis of spontaneous bacterial peritonitis and prediction of in-hospital mortality in patients with decompensated cirrhosis.Medicine · 2019
Article
Beneficial role of bioactive lipids in the pathobiology, prevention, and management of HBV, HCV and alcoholic hepatitis, NAFLD, and liver cirrhosis: A review.Journal of advanced research · 2019
Review
Gut-Liver Axis Links Portal Hypertension to Acute-on-Chronic Liver Failure.Visceral medicine · 2018
Review

4 · The record

Corrections and comments

Comment on
Immunosuppression in acutely decompensated cirrhosis is mediated by prostaglandin E2.2014

5 · Who and what money

Authors and funding

2 authors.

Vicente ArroyoLiver Unit, Hospital Clinic, Centre Esther Koplowitz, Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain, and at Centro de Investigación Biomédica en Red, Barcelona, Spain.

Richard MoreauINSERM UMR S 1149, Centre de Recherche sur l'Inflammation, Paris, France, Université Paris Diderot, Faculté de Médecine, Paris, France, and Département Hospitalo-Universitaire UNITY, Service d'Hépatologie, Hôpital Beaujon, Assistance Publique-Hôpitaux de Paris, Clichy, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Immunity, InnateAnimalsDinoprostoneFibrosisHumansReceptors, Prostaglandin E, EP2 SubtypeDinoprostoneReceptors, Prostaglandin E, EP2 Subtype

Identifiers

PMID24804750

DOI10.1038/nm.3553

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.