ArticlePloS one2014
Oral vaccination of white-tailed deer (Odocoileus virginianus) with Mycobacterium bovis Bacillus Calmette-Guerin (BCG).
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed.
- Tuberculosis vaccination: microbiological and immunological summary of a series of experimental challenge studies.Veterinary research · 2025Article
- Oral delivery of Mycobacterium bovis bacillus Calmette-Guérin (BCG) in alginate spheres to captive white-tailed deer.BMC veterinary research · 2025Article
- Orally administered live BCG and heat-inactivated Mycobacterium bovis protect bison against experimental bovine tuberculosis.Scientific reports · 2025Article
- Immune responses of cattle vaccinated by various routes with Mycobacterium bovis Bacillus Calmette-Guérin (BCG).BMC veterinary research · 2025Article
- Oral delivery of bovine tuberculosis vaccine to free-ranging white-tailed deer.Frontiers in veterinary science · 2025Article
- Progress and persistence of diseases of high consequence to livestock in the United States.One health (Amsterdam, Netherlands) · 2024Review
- Use of rhodamine B as a biomarker in a simulated oral vaccine deployment against bovine tuberculosis in white-tailed deer.Frontiers in veterinary science · 2024Article
- Evaluation of alternative vaccination routes against paratuberculosis in goats.Frontiers in veterinary science · 2024Article
- Vaccination of White-Tailed Deer withMicroorganisms · 2023Article
- Differential induction of innate memory in porcine monocytes byInnate immunity · 2021Article
- Bovine Tuberculosis: The Emergence of a New Wildlife Maintenance Host in Ireland.Frontiers in veterinary science · 2021Article
- Development and Challenges in Animal Tuberculosis Vaccination.Pathogens (Basel, Switzerland) · 2020Review
- Article
- Baiting studies on oral vaccination of the greater kudu (European journal of wildlife research · 2018Article
- Use of the Human Vaccine,Frontiers in veterinary science · 2018Review
- Persistent Spillback of Bovine Tuberculosis From White-Tailed Deer to Cattle in Michigan, USA: Status, Strategies, and Needs.Frontiers in veterinary science · 2018Review
- Using White-tailed Deer (Journal of the American Association for Laboratory Animal Science : JAALAS · 2017Article
- Article
- Oral Vaccination with Heat-InactivatedFrontiers in veterinary science · 2017Article
- Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Wildlife reservoirs of Mycobacterium bovis represent serious obstacles to the eradication of tuberculosis from livestock, particularly cattle. In Michigan, USA tuberculous white-tailed deer transmit M. bovis to other deer and cattle. One approach in dealing with this wildlife reservoir is to vaccinate deer, thus interfering with the intraspecies and interspecies transmission cycles. Thirty-three white-tailed deer were assigned to one of two groups; oral vaccination with 1 × 10(8) colony-forming units of M. bovis BCG Danish (n = 17); and non-vaccinated (n = 16). One hundred eleven days after vaccination deer were infected intratonsilarly with 300 colony-forming units of virulent M. bovis. At examination, 150 days after challenge, BCG vaccinated deer had fewer gross and microscopic lesions, fewer tissues from which M. bovis could be isolated, and fewer late stage granulomas with extensive liquefactive necrosis. Fewer lesions, especially those of a highly necrotic nature should decrease the potential for dissemination of M. bovis within the host and transmission to other susceptible hosts.
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Registered trials
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