ArticleEthnicity & disease2014
High factor VIII, von Willebrand factor, and fibrinogen levels and risk of venous thromboembolism in blacks and whites.
Article in Ethnicity & disease, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 38 citations in OpenAlex.
- Correlation between serum factor VIII:C levels and deep vein thrombosis following gynecological surgery.Bioengineered · 2021Trial
- RAB5C Increases Endothelial Release of VWF by Regulating Vesicle Trafficking.Arteriosclerosis, thrombosis, and vascular biology · 2026Article
- Blood coagulation factors and risk of venous thromboembolism: a population-based study.European journal of medical research · 2026Article
- Development and validation of deep vein thrombosis diagnostic model based on machine learning methods.Annals of hematology · 2025Article
- Pregnancy-associated venous thromboembolism in sub-Saharan Africa: a case-control study and descriptive analysis of clinical phenotypes.Research and practice in thrombosis and haemostasis · 2025Article
- Evaluation of factors underlying differences in venous thromboembolism rates between Black and White patients.Journal of vascular surgery. Venous and lymphatic disorders · 2025Article
- Uterine Fibroids and Their Association with Acute and Chronic Venous Thromboembolic Disease-An Expert Review of the Literature.Journal of clinical medicine · 2025Review
- Factor VIII and Incident Hypertension in Black and White Adults: The REasons for Geographic and Racial Differences in Stroke (REGARDS) Cohort.American journal of hypertension · 2024Article
- Article
- Laboratory-based inequity in thrombosis and hemostasis: review of the evidence.Research and practice in thrombosis and haemostasis · 2023Review
- Contemporary Biomarkers in Pulmonary Embolism Diagnosis: Moving beyond D-Dimers.Journal of personalized medicine · 2022Review
- Plasma levels of von Willebrand factor and future risk of incident venous thromboembolism.Blood advances · 2021Article
- Monitoring of Unfractionated Heparin in Severe COVID-19: An Observational Study of Patients on CRRT and ECMO.TH open : companion journal to thrombosis and haemostasis · 2020Article
- Molecular mechanisms for thrombosis risk in Black people: a role in excess mortality from COVID-19.British journal of haematology · 2020Article
- FVIII half-life extension by coadministration of a D'D3 albumin fusion protein in mice, rabbits, rats, and monkeys.Blood advances · 2020Article
- From Classical Laboratory Parameters to Novel Biomarkers for the Diagnosis of Venous Thrombosis.International journal of molecular sciences · 2020Review
- Review
- Review
- Clinical and Prognostic Significance of Lupus Anticoagulant Measurement in Patients With Lung Cancer.Technology in cancer research & treatment · 2017Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Venous thromboembolism (VTE) affects more than 300,000 people in the United States each year. However, it has been estimated that current diagnostic testing fails to identify prothrombotic risk in 50% of VTE patients. This article examines the relationship between levels of the pro-coagulant proteins factor VIII (FVIII), von Willebrand factor (VWF), and fibrinogen and risk of VTE in order to assess the impact of these novel risk factors. Data were collected from patients enrolled in the matched case-control Genetic Attributes and Thrombosis Epidemiology study. Crude and adjusted conditional logistic regression models were used to assess the impact of FVIII, VWF, and fibrinogen on risk of VTE. Before adjustment for independent predictors of VTE risk, high levels of FVIII, VWF, and fibrinogen were significantly associated with increased risk of VTE in both Blacks and Whites. After adjustment for ABO type, factor VII levels, hypertension, renal disease, recent surgery, diabetes, annual household income, alcohol use, and the other proteins of interest (FVIII, VWF, and/or fibrinogen), high FVIII and VWF levels were associated with increased risk of VTE in Blacks (OR: 1.97 [1.01-3.84] and 3.39 [1.58-7.27], respectively). High FVIII only was significantly associated with risk of VTE in Whites (OR: 2.35 [1.16-4.75]). Future research into the inclusion of these protein levels in risk models for VTE could help identify persons at highest risk.
Indexed as
Identifiers
24804362PMC4618385W193566726What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.