Evidence map›Paper›PMID 24804234›Full record

ArticleBioMed research international2014

Patterns in the parathyroid response to sodium bicarbonate infusion test in healthy volunteers.

Theodossis S Papavramidis, Olympia E Anastasiou, Ioannis Pliakos, Nick Michalopoulos, Mike Polyzonis, Konstantina Triantafyllopoulou, Georgia Kokaraki, Spiros Papavramidis

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Article in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Theodossis S Papavramidis3rd Department of Surgery, AHEPA University Hospital, Aristotle University of Thessaloniki, Thessaloniki, 54655 Macedonia, Greece.
Olympia E AnastasiouDepartment of Endocrinology and Metabolism, AHEPA University Hospital, Aristotle University of Thessaloniki, Thessaloniki, 54655 Macedonia, Greece.
Ioannis Pliakos3rd Department of Surgery, AHEPA University Hospital, Aristotle University of Thessaloniki, Thessaloniki, 54655 Macedonia, Greece.
Nick Michalopoulos3rd Department of Surgery, AHEPA University Hospital, Aristotle University of Thessaloniki, Thessaloniki, 54655 Macedonia, Greece.ORCID 0000-0002-7740-4922
Mike Polyzonis3rd Department of Surgery, AHEPA University Hospital, Aristotle University of Thessaloniki, Thessaloniki, 54655 Macedonia, Greece.ORCID 0000-0002-2379-0477
Konstantina Triantafyllopoulou3rd Department of Surgery, AHEPA University Hospital, Aristotle University of Thessaloniki, Thessaloniki, 54655 Macedonia, Greece.
Georgia KokarakiDepartment of Immunology, AHEPA University Hospital, Aristotle University of Thessaloniki, Thessaloniki, 54655 Macedonia, Greece.
Spiros Papavramidis3rd Department of Surgery, AHEPA University Hospital, Aristotle University of Thessaloniki, Thessaloniki, 54655 Macedonia, Greece.
Aristotle University of Thessaloniki · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe sodium bicarbonate infusion test evaluates the function of the parathyroid glands. The present study aims to evaluate the range of parathyroid response in healthy individuals and the potential influence of various factors.

methodsFifty healthy volunteers were subjected to the test. Levels of vitamin D, calcium, albumin, and PTH were measured before infusion. PTH was measured at 3, 5, 10, 30, and 60 minutes after infusion.

resultsA curve describing the response of parathyroids to the test was drawn. Twenty percent of the subjects had blunted PTH response. No significant difference was observed between normal and blunted responders concerning age, BMI, baseline PTH, or calcium levels. Nonetheless, there was a significant difference in vitamin D levels (P = 0.024).

interpretationThe test is easy to perform and may be used for everyday screening. It has to be clarified whether our observations are, at least partly, produced due to the presence of individuals with a constitutively blunted response or if low levels of vitamin D decrease the ability of the parathyroids to respond. Whichever the case, PTH response of normal individuals to sodium bicarbonate infusion test is more varied than previously thought and vitamin D levels influence it.

Indexed as

AdultAlbuminsCalciumHealthy VolunteersHumansMiddle AgedParathyroid GlandsParathyroid HormoneSodium BicarbonateVitamin DAlbuminsCalciumParathyroid HormoneSodium BicarbonateVitamin D

Identifiers

PMID24804234
PMCPMC3997070
OpenAlexW2121630844

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.