Evidence map›Paper›PMID 24804228›Full record

ArticleBioMed research international2014

The chromosome 9p21 variant not predicting long-term cardiovascular mortality in Chinese with established coronary artery disease: an eleven-year follow-up study.

I-Te Lee, Mark O Goodarzi, Wen-Jane Lee, Jerome I Rotter, Yii-der Ida Chen, Kae-Woei Liang, Wen-Lieng Lee, Wayne H-H Sheu

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

I-Te LeeDivision of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung 40705, Taiwan ; School of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan ; School of Medicine, National Yang-Ming University, Taipei 11221, Taiwan.
Mark O GoodarziDivision of Endocrinology, Diabetes and Metabolism, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA ; Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Wen-Jane LeeDepartment of Medical Research, Taichung Veterans General Hospital, Taichung 40705, Taiwan.
Jerome I RotterMedical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Yii-der Ida ChenMedical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA ; Department of Ob/Gyn, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Kae-Woei LiangCardiovascular Center, Taichung Veterans General Hospital, Taichung 40705, Taiwan.
Wen-Lieng LeeCardiovascular Center, Taichung Veterans General Hospital, Taichung 40705, Taiwan.ORCID 0000-0003-1956-7122
Wayne H-H SheuDivision of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung 40705, Taiwan ; School of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan ; School of Medicine, National Yang-Ming University, Taipei 11221, Taiwan.
Cedars-Sinai Medical Center · USTaichung Veterans General Hospital · TWNational Yang Ming Chiao Tung University · TW

Funding

UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PETER J TONTONOZ · 2003 to 2026
$40.4M
NCATS NIH HHS UL1 TR000124NIDDK NIH HHS P30 DK063491
6 · The paper itself

Abstract

introductionWe examined whether the variant at chromosome 9p21, rs4977574, was associated with long-term cardiovascular mortality in Han Chinese patients with coronary artery disease (CAD). METHODOLOGY: Subjects who underwent coronary angiography for chest pain were consecutively enrolled. Fasting blood samples were collected for laboratory and genotype assessments. The information was correlated with data collected from the national death database.

resultsThere were 925 cases with CAD and 634 without CAD enrolled in the present study. The G allele conferred a significant increase in risk of CAD (odds ratio = 1.47, P = 0.003 in the dominant model; odds ratio = 1.36, P = 0.018 in the recessive model). During a median of 11 years (inter-quartile range between 5.2 and 12.5 years) of follow-up, neither the total nor the cardiovascular mortality was different among CAD subjects with different genotypes. Using Cox regression analysis, genotypes of rs4977574 still failed to predict cardiovascular mortality (hazard ratio = 1.25, P = 0.138 in the dominant model; hazard ratio = 1.05, P = 0.729 in the recessive model).

conclusionsThe rs4977574 at chromosome 9p21 is associated with presence of CAD in Han Chinese. However, rs4977574 could not predict cardiovascular mortality in these CAD subjects during the eleven-year period of the study.

Indexed as

PrognosisAgedAsian PeopleCardiovascular DiseasesChinaChromosomes, Human, Pair 9Coronary AngiographyCoronary Artery DiseaseFemaleFollow-Up StudiesHumansMaleMiddle AgedPolymorphism, Single NucleotideRisk Factors

Identifiers

PMID24804228
PMCPMC3996981
OpenAlexW2045747283

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.