ArticleBioResearch open access2014
Follow-up of implant survival comparing ficoll and bone marrow aspirate concentrate methods for hard tissue regeneration with mesenchymal stem cells in humans.
Article in BioResearch open access, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05465421 (Clinical and Radiographic Assessment of Buccolingual Bone Dimension Following Socket Preservation With Bone Marrow Mono-nuclear Cell From the Maxillary Tuberosity Combined With Platelet-rich Fibrin Compared With Platelet-rich Fibrin Alone), which is not on this map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Clinical and Radiographic Assessment of Buccolingual Bone Dimension Following Socket Preservation With Bone Marrow Mono-nuclear Cell From the Maxillary Tuberosity Combined With Platelet-rich Fibrin Compared With Platelet-rich Fibrin Alone
Who cites it
10 citing papers in PubMed, 26 citations in OpenAlex.
- Ligation of Intersphincteric Fistula Tract (LIFT) with or Without Injection of Bone Marrow Mononuclear Cells in the Treatment of Trans-sphincteric Anal Fistula: a Randomized Controlled Trial.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2022Trial
- Clinical Application of Cell-Based Approaches in Maxillary Sinus Floor Augmentation: A Systematic Review and Meta-Analysis.Bioengineering (Basel, Switzerland) · 2025Review
- Repair of Critical Size Bone Defects Using Synthetic Hydroxyapatite or Xenograft with or without the Bone Marrow Mononuclear Fraction: A Histomorphometric and Immunohistochemical Study in Rat Calvaria.Materials (Basel, Switzerland) · 2021Article
- Autologous cell-based therapy for treatment of large bone defects: from bench to bedside.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2018Review
- Reduction of relative centrifugation force within injectable platelet-rich-fibrin (PRF) concentrates advances patients' own inflammatory cells, platelets and growth factors: the first introduction to the low speed centrifugation concept.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2018Article
- Treatment of stage II medication-related osteonecrosis of the jaw with necrosectomy and autologous bone marrow mesenchymal stem cells.Odontology · 2017Article
- Increased microRNA-93-5p inhibits osteogenic differentiation by targeting bone morphogenetic protein-2.PloS one · 2017Article
- Safety and feasibility of cell-based therapy of autologous bone marrow-derived mononuclear cells in plate-stabilized proximal humeral fractures in humans.Journal of translational medicine · 2016Article
- Mesenchymal stem cells in maxillary sinus augmentation: A systematic review with meta-analysis.World journal of stem cells · 2015Article
- Endothelial Progenitor Cell Fraction Contained in Bone Marrow-Derived Mesenchymal Stem Cell Populations Impairs Osteogenic Differentiation.BioMed research international · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveClinical follow-up of implant survival in 11 patients comparing two different methods for mesenchymal stem cell (MSC) isolation (Ficoll and bone marrow aspirate concentrate [BMAC]) applied in maxillary sinus augmentation.
methodsMononuclear cells, including MSCs, were concentrated with either Ficoll (control group, n=6 sinus) or BMAC (test group, n=12 sinus) and transplanted in combination with bovine bone mineral. A total of 50 implants were placed in a second surgical intervention (17 Ficoll/33 BMAC) and loaded after 4 months. Overall implant survival was assessed with a Kaplan-Meier model using package survival under R.
resultsImplant survival of the Ficoll group was 100% compared with the BMAC group, which had 93.4% survival (95% confidence interval, 0.849-1). The difference between the groups was not significant (p=0.381).
conclusionThe BMAC system is an effective and suitable "chair-side" method for clinical application in hard tissue regeneration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.