Evidence map›Paper›PMID 24804104›Full record

ArticleNeural plasticity2014

Comparing the efficacy of excitatory transcranial stimulation methods measuring motor evoked potentials.

Vera Moliadze, Georg Fritzsche, Andrea Antal

Abstract readComparative Study
In one paragraph

Article in Neural plasticity, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Vera MoliadzeDepartment of Clinical Neurophysiology, University Medical Center, Georg-August University of Göttingen, Robert-Koch-Straße 40, 37075 Göttingen, Germany ; Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Goethe University of Frankfurt am Main, Deutschordenstraße 50 (House 92), 60528 Frankfurt am Main, Germany.ORCID 0000-0001-9241-9922
Georg FritzscheDepartment of Clinical Neurophysiology, University Medical Center, Georg-August University of Göttingen, Robert-Koch-Straße 40, 37075 Göttingen, Germany.
Andrea AntalDepartment of Clinical Neurophysiology, University Medical Center, Georg-August University of Göttingen, Robert-Koch-Straße 40, 37075 Göttingen, Germany.ORCID 0000-0001-9671-8946

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The common aim of transcranial stimulation methods is the induction or alterations of cortical excitability in a controlled way. Significant effects of each individual stimulation method have been published; however, conclusive direct comparisons of many of these methods are rare. The aim of the present study was to compare the efficacy of three widely applied stimulation methods inducing excitability enhancement in the motor cortex: 1 mA anodal transcranial direct current stimulation (atDCS), intermittent theta burst stimulation (iTBS), and 1 mA transcranial random noise stimulation (tRNS) within one subject group. The effect of each stimulation condition was quantified by evaluating motor-evoked-potential amplitudes (MEPs) in a fixed time sequence after stimulation. The analyses confirmed a significant enhancement of the M1 excitability caused by all three types of active stimulations compared to sham stimulation. There was no significant difference between the types of active stimulations, although the time course of the excitatory effects slightly differed. Among the stimulation methods, tRNS resulted in the strongest and atDCS significantly longest MEP increase compared to sham. Different time courses of the applied stimulation methods suggest different underlying mechanisms of action. Better understanding may be useful for better targeting of different transcranial stimulation techniques.

Indexed as

AdultAnalysis of VarianceBrainData Interpretation, StatisticalElectric StimulationEvoked Potentials, MotorFemaleHumansMalePyramidal TractsYoung Adult

Identifiers

PMID24804104
PMCPMC3997131

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.