Evidence map›Paper›PMID 24803993›Full record

ArticleThe journal of physical chemistry letters2014

Contraction-Induced Changes in Hydrogen Bonding of Muscle Hydration Water.

Hyok Yoo, Ekaterina Nagornyak, Ronnie Das, Adam D Wexler, Gerald H Pollack

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of physical chemistry letters, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Hyok YooDepartment of Bioengineering, University of Washington , Box 355061, Seattle, Washington 98195, United States.
Ekaterina NagornyakDepartment of Bioengineering, University of Washington , Box 355061, Seattle, Washington 98195, United States.
Ronnie DasDepartment of Bioengineering, University of Washington , Box 355061, Seattle, Washington 98195, United States.
Adam D WexlerWetsus Center for Sustainable Water Technology , Agora 1, 8900CC Leeuwarden, The Netherlands.
Gerald H PollackDepartment of Bioengineering, University of Washington , Box 355061, Seattle, Washington 98195, United States.
University of Washington · US

Funding

Unexpectedly Profound Role of Water in Biology and MedicineR01GM093842 · NIGMS · UNIVERSITY OF WASHINGTON · PI POLLACK, GERALD H · 2009 to 2013
$3.7M
NIGMS NIH HHS R01 GM093842
6 · The paper itself

Abstract

Protein-water interaction plays a crucial role in protein dynamics and hence function. To study the chemical environment of water and proteins with high spatial resolution, synchrotron radiation-Fourier transform infrared (SR-FTIR) spectromicroscopy was used to probe skeletal muscle myofibrils. Observing the OH stretch band showed that water inside of relaxed myofibrils is extensively hydrogen-bonded with little or no free OH. In higher-resolution measurements obtained with single isolated myofibrils, the water absorption peaks were relatively higher within the center region of the sarcomere compared to those in the I-band region, implying higher hydration capacity of thick filaments compared to the thin filaments. When specimens were activated, changes in the OH stretch band showed significant dehydrogen bonding of muscle water; this was indicated by increased absorption at ∼3480 cm

Identifiers

PMID24803993
PMCPMC3985702
OpenAlexW2325304676

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.