Evidence map›Paper›PMID 24803959›Full record

ArticleBiomicrofluidics2014

A microfluidic model for organ-specific extravasation of circulating tumor cells.

R Riahi, Y L Yang, H Kim, L Jiang, P K Wong, Y Zohar

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomicrofluidics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 56 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Breast tumor-on-chip models: From disease modeling to personalized drug screening.Journal of controlled release : official journal of the Controlled Release Society · 2021
    Review
  11. Article
  12. Article
  13. Review
  14. Review
  15. Review
  16. Review
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

R RiahiDepartment of Aerospace and Mechanical Engineering, The University of Arizona, Tucson, Arizona 85719, USA.
Y L YangDepartment of Aerospace and Mechanical Engineering, The University of Arizona, Tucson, Arizona 85719, USA.
H KimDepartment of Molecular and Cellular Biology, The University of Arizona, Tucson, Arizona 85719, USA.
L JiangDepartment of Aerospace and Mechanical Engineering, The University of Arizona, Tucson, Arizona 85719, USA ; College of Optical Science, The University of Arizona, Tucson, Arizona 85719, USA.
P K WongDepartment of Aerospace and Mechanical Engineering, The University of Arizona, Tucson, Arizona 85719, USA ; Department of Biomedical Engineering, The University of Arizona, Tucson, Arizona 85719, USA ; BIO5 Institute, The University of Arizona, Tucson, Arizona 85719, USA.
Y ZoharDepartment of Aerospace and Mechanical Engineering, The University of Arizona, Tucson, Arizona 85719, USA ; Department of Biomedical Engineering, The University of Arizona, Tucson, Arizona 85719, USA ; BIO5 Institute, The University of Arizona, Tucson, Arizona 85719, USA ; Arizona Cancer Center, The University of Arizona, Tucson, Arizona 85719, USA.
University of Arizona · USBIO5 Institute

Funding

Mechanoregulation of Tissue MorphogenesisDP2OD007161 · OD · UNIVERSITY OF ARIZONA · PI WONG, PAK KIN · 2010 to 2010
$2.3M
NIH HHS DP2 OD007161
6 · The paper itself

Abstract

Circulating tumor cells (CTCs) are the principal vehicle for the spread of non-hematologic cancer disease from a primary tumor, involving extravasation of CTCs across blood vessel walls, to form secondary tumors in remote organs. Herein, a polydimethylsiloxane-based microfluidic system is developed and characterized for in vitro systematic studies of organ-specific extravasation of CTCs. The system recapitulates the two major aspects of the in vivo extravasation microenvironment: local signaling chemokine gradients in a vessel with an endothelial monolayer. The parameters controlling the locally stable chemokine gradients, flow rate, and initial chemokine concentration are investigated experimentally and numerically. The microchannel surface treatment effect on the confluency and adhesion of the endothelial monolayer under applied shear flow has also been characterized experimentally. Further, the conditions for driving a suspension of CTCs through the microfluidic system are discussed while simultaneously maintaining both the local chemokine gradients and the confluent endothelial monolayer. Finally, the microfluidic system is utilized to demonstrate extravasation of MDA-MB-231 cancer cells in the presence of CXCL12 chemokine gradients. Consistent with the hypothesis of organ-specific extravasation, control experiments are presented to substantiate the observation that the MDA-MB-231 cell migration is attributed to chemotaxis rather than a random process.

Identifiers

PMID24803959
PMCPMC3987064
OpenAlexW1997148600

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.