ArticleJournal of tropical medicine2014
Role of Clinical Presentations and Routine CSF Analysis in the Rapid Diagnosis of Acute Bacterial Meningitis in Cases of Negative Gram Stained Smears.
Article in Journal of tropical medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 40 citations in OpenAlex.
- Virtual Gram staining of label-free bacteria using dark-field microscopy and deep learning.Science advances · 2025Article
- Clinical presentations and microbiological analysis of cerebrospinal fluid samples in cases of suspected bacterial meningitis patients attending a 1600 bedded teaching hospital from 2019 to 2022: A retrospective study.Journal of family medicine and primary care · 2023Article
- Article
- Use of a new multiplex quantitative polymerase chain reaction based assay for simultaneous detection ofIranian journal of microbiology · 2021Article
- Microbial aspects and potential markers for differentiation between bacterial and viral meningitis among adult patients.PloS one · 2021Article
- Infectious Complications of Expanded Endoscopic Transsphenoidal Surgery: A Retrospective Cohort Analysis of 100 Cases.Journal of neurological surgery. Part B, Skull base · 2020Article
- Use of the Sysmex XT-4000i hematology analyzer in the differentiation of cerebrospinal fluid cells in children.Journal of clinical laboratory analysis · 2019Article
- New molecular tools for meningitis diagnostics in Ethiopia - a necessary step towards improving antimicrobial prescription.BMC infectious diseases · 2018Article
- Identification of Common Bacterial Pathogens Causing Meningitis in Culture-Negative Cerebrospinal Fluid Samples Using Real-Time Polymerase Chain Reaction.International journal of microbiology · 2016Article
- Laboratory-based clinical audit as a tool for continual improvement: an example from CSF chemistry turnaround time audit in a South-African teaching hospital.Biochemia medica · 2016Article
- Epidemiology and Risk Factors Associated with Developing Bacterial Meningitis among Children in Gaza Strip.Iranian journal of public health · 2014Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Aim. Bacterial meningitis is a lethal, disabling endemic disease needing prompt antibiotic management. Gram stained smears is rapid accurate method for diagnosis of bacterial meningitis. In cases of negative gram stained smears diagnosis is delayed till culture results. We aim to assess the role of clinical presentations and routine CSF analysis in the cost-effective rapid diagnosis of negative gram stained smears bacterial meningitis. Methods. Cross sectional study including 623 acute meningitis patients divided into two groups: bacterial meningitis and nonbacterial meningitis groups. The clinical presentations, systemic inflammatory parameters, and CSF analysis were evaluated and compared in both groups. Results. Altered conscious level, localizing neurological signs, Kernig's and Brudzinski's signs together with peripheral leucocytosis (>10.000/mm(3)), high CRP (>6) together with high CSF protein (>50 gl/dL), CSF neutrophilic count (≥50% of total CSF leucocytic count), and low CSF glucose level (<45 gm/dL) and CSF/serum glucose ≤0.6 were significantly diagnostic in bacterial meningitis patients. From the significant CSF analysis variables CSF protein carried the higher accuracy of diagnosis 78% with sensitivity 88% and specificity 72%. Conclusions. High CSF protein (>50 mg/dL) together with plasma inflammatory markers and CSF cytochemical parameters can diagnose bacterial meningitis in gram stain negative smear till culture results.
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