ReviewFrontiers in neurology2014
Cervical dystonia: a disorder of the midbrain network for covert attentional orienting.
Review in Frontiers in neurology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Altered sensorimotor activation patterns in idiopathic dystonia-an activation likelihood estimation meta-analysis of functional brain imaging studies.Human brain mapping · 2016Pooled it
- Temporal discrimination at the neck region is associated with severity of cervical dystonia.Scientific reports · 2025Article
- Abnormal Connectivity of the Head Neural Integrator in Cervical Dystonia.Movement disorders : official journal of the Movement Disorder Society · 2025Observational
- Autoimmune brainstem encephalitis: Clinical associations, outcomes, and proposed diagnostic criteria.Annals of clinical and translational neurology · 2025Article
- Implicit Selective Attention: The Role of the Mesencephalic-basal Ganglia System.Current neuropharmacology · 2024Review
- What Are the Functions of the Superior Colliculus and Its Involvement in Neurologic Disorders?Neurology · 2023Article
- Characterizing the temporal discrimination threshold in musician's dystonia.Scientific reports · 2022Article
- Longitudinal Follow-Up of Mood in Cervical Dystonia and Influence on Age at Onset.Movement disorders clinical practice · 2022Article
- Reliability of DNMSQuest as a Screening Tool for Mood Disorders in Cervical Dystonia.Movement disorders clinical practice · 2021Article
- Does the network model fits neurophysiological abnormalities in blepharospasm?Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020Review
- Sex differences in movement disorders.Nature reviews. Neurology · 2020Review
- Application of real-time shear wave elastography in the assessment of torsional cervical dystonia.Quantitative imaging in medicine and surgery · 2019Article
- Temporal Discrimination Thresholds and Proprioceptive Performance: Impact of Age and Nerve Conduction.Frontiers in neuroscience · 2019Article
- Wnt signal activation induces midbrain specification through direct binding of the beta-catenin/TCF4 complex to the EN1 promoter in human pluripotent stem cells.Experimental & molecular medicine · 2018Article
- Measurement & Analysis of the Temporal Discrimination Threshold Applied to Cervical Dystonia.Journal of visualized experiments : JoVE · 2018Article
- Reduced Frequency of Ipsilateral Express Saccades in Cervical Dystonia: Probing the Nigro-Tectal Pathway.Tremor and other hyperkinetic movements (New York, N.Y.) · 2018Article
- Disrupted superior collicular activity may reveal cervical dystonia disease pathomechanisms.Scientific reports · 2017Article
- Temporal Discrimination: Mechanisms and Relevance to Adult-Onset Dystonia.Frontiers in neurology · 2017Review
- Association Analysis of NALCN Polymorphisms rs1338041 and rs61973742 in a Chinese Population with Isolated Cervical Dystonia.Parkinson's disease · 2016Article
- Cross-species comparison of anticipatory and stimulus-driven neck muscle activity well before saccadic gaze shifts in humans and nonhuman primates.Journal of neurophysiology · 2015Article
Corrections and comments
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Authors and funding
14 authors at 8 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While the pathogenesis of cervical dystonia remains unknown, recent animal and clinical experimental studies have indicated its probable mechanisms. Abnormal temporal discrimination is a mediational endophenotype of cervical dystonia and informs new concepts of disease pathogenesis. Our hypothesis is that both abnormal temporal discrimination and cervical dystonia are due to a disorder of the midbrain network for covert attentional orienting caused by reduced gamma-aminobutyric acid (GABA) inhibition, resulting, in turn, from as yet undetermined, genetic mutations. Such disinhibition is (a) subclinically manifested by abnormal temporal discrimination due to prolonged duration firing of the visual sensory neurons in the superficial laminae of the superior colliculus and (b) clinically manifested by cervical dystonia due to disinhibited burst activity of the cephalomotor neurons of the intermediate and deep laminae of the superior colliculus. Abnormal temporal discrimination in unaffected first-degree relatives of patients with cervical dystonia represents a subclinical manifestation of defective GABA activity both within the superior colliculus and from the substantia nigra pars reticulata. A number of experiments are required to prove or disprove this hypothesis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.