ArticleJournal of applied physics2014
Magnetic approaches to study collective three-dimensional cell mechanics in long-term cultures (invited).
Article in Journal of applied physics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Light-driven biological actuators to probe the rheology of 3D microtissues.Nature communications · 2023Article
- Measuring Cytoskeletal Mechanical Fluctuations and Rheology with Active Micropost Arrays.Current protocols · 2022Article
- Engineered skeletal muscles for disease modeling and drug discovery.Biomaterials · 2019Review
- Matrix viscoplasticity and its shielding by active mechanics in microtissue models: experiments and mathematical modeling.Scientific reports · 2016Article
- A microfabricated magnetic actuation device for mechanical conditioning of arrays of 3D microtissues.Lab on a chip · 2015Article
- Traction Force Microscopy for Noninvasive Imaging of Cell Forces.Advances in experimental medicine and biologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Contractile forces generated by cells and the stiffness of the surrounding extracellular matrix are two central mechanical factors that regulate cell function. To characterize the dynamic evolution of these two mechanical parameters during tissue morphogenesis, we developed a magnetically actuated micro-mechanical testing system in which fibroblast-populated collagen microtissues formed spontaneously in arrays of microwells that each contains a pair of elastomeric microcantilevers. We characterized the magnetic actuation performance of this system and evaluated its capacity to support long-term cell culture. We showed that cells in the microtissues remained viable during prolonged culture periods of up to 15 days, and that the mechanical properties of the microtissues reached and maintained at a stable state after a fast initial increase stage. Together, these findings demonstrate the utility of this microfabricated bio-magneto-mechanical system in extended mechanobiological studies in a physiologically relevant 3D environment.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.