ArticleDevelopment (Cambridge, England)2014
The development of zebrafish tendon and ligament progenitors.
Article in Development (Cambridge, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
60 citing papers in PubMed, 113 citations in OpenAlex.
- Gene regulatory programs underlying diversification of facial ligaments and tendons in zebrafish.Development (Cambridge, England) · 2026Article
- Comparing the expression patterns and differences of LOX and LOXL1 during the development of myodural bridge and ligamentum flavum.Frontiers in cell and developmental biology · 2026Article
- Article
- Single-cell profiling of the amphioxus digestive tract reveals conservation of endocrine cells in chordates.Science advances · 2024Article
- A conserved transcription factor regulatory program promotes tendon fate.Developmental cell · 2024Article
- Zebrafish Models for Skeletal and Extraskeletal Osteogenesis Imperfecta Features: Unveiling Pathophysiology and Paving the Way for Drug Discovery.Calcified tissue international · 2024Review
- Animal models of tendon calcification: Past, present, and future.Animal models and experimental medicine · 2024Review
- The proteasome subunit psmb1 is essential for craniofacial cartilage maturation and morphogenesis.JCI insight · 2024Article
- Standardization of zebrafish drug testing parameters for muscle diseases.Disease models & mechanisms · 2024Article
- Single-cell analysis reveals distinct fibroblast plasticity during tenocyte regeneration in zebrafish.Science advances · 2023Article
- Earlier proteoglycan turnover promotes higher efficiency matrix remodeling in MRL/MpJ tendons.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2023Article
- Endogenous tenocyte activation underlies the regenerative capacity of the adult zebrafish tendon.NPJ Regenerative medicine · 2023Article
- Zebrafish crocc2 mutants exhibit divergent craniofacial shape, misregulated variability, and aberrant cartilage morphogenesis.Developmental dynamics : an official publication of the American Association of Anatomists · 2023Article
- Directionality of developing skeletal muscles is set by mechanical forces.Nature communications · 2023Article
- Nuclear receptor Nr5a2 promotes diverse connective tissue fates in the jaw.Developmental cell · 2023Article
- Review
- Differentiation and Maturation of Muscle and Fat Cells in Cultivated Seafood: Lessons from Developmental Biology.Marine biotechnology (New York, N.Y.) · 2023Review
- Coordinated patterning of zebrafish caudal fin symmetry by a central and two peripheral organizers.Developmental dynamics : an official publication of the American Association of Anatomists · 2022Article
- The impact of Drew Noden's work on our understanding of craniofacial musculoskeletal integration.Developmental dynamics : an official publication of the American Association of Anatomists · 2022Review
- Patterning of cartilaginous condensations in the developing facial skeleton.Developmental biology · 2022Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Despite the importance of tendons and ligaments for transmitting movement and providing stability to the musculoskeletal system, their development is considerably less well understood than that of the tissues they serve to connect. Zebrafish have been widely used to address questions in muscle and skeletal development, yet few studies describe their tendon and ligament tissues. We have analyzed in zebrafish the expression of several genes known to be enriched in mammalian tendons and ligaments, including scleraxis (scx), collagen 1a2 (col1a2) and tenomodulin (tnmd), or in the tendon-like myosepta of the zebrafish (xirp2a). Co-expression studies with muscle and cartilage markers demonstrate the presence of scxa, col1a2 and tnmd at sites between the developing muscle and cartilage, and xirp2a at the myotendinous junctions. We determined that the zebrafish craniofacial tendon and ligament progenitors are neural crest derived, as in mammals. Cranial and fin tendon progenitors can be induced in the absence of differentiated muscle or cartilage, although neighboring muscle and cartilage are required for tendon cell maintenance and organization, respectively. By contrast, myoseptal scxa expression requires muscle for its initiation. Together, these data suggest a conserved role for muscle in tendon development. Based on the similarities in gene expression, morphology, collagen ultrastructural arrangement and developmental regulation with that of mammalian tendons, we conclude that the zebrafish tendon populations are homologous to their force-transmitting counterparts in higher vertebrates. Within this context, the zebrafish model can be used to provide new avenues for studying tendon biology in a vertebrate genetic system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.