Evidence map›Paper›PMID 24803633›Full record

ArticleClinical pediatrics2014

Clinically relevant pharmacogenomic testing in pediatric practice.

Lindsey Korbel, Mathew George, Joseph Kitzmiller

Abstract read
In one paragraph

Article in Clinical pediatrics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Lindsey KorbelThe Ohio State University College of Medicine, Columbus, OH, USA lindsey.korbel@osumc.edu.
Mathew GeorgeSt Barnabas Hospital, Bronx, NY, USA.
Joseph KitzmillerThe Ohio State University College of Medicine, Columbus, OH, USA.
The Ohio State University · USSt. Barnabas Hospital · US

Funding

Statin Pharmacogenomics: A multi-gene PK-PD modeling approachK23GM100372 · NIGMS · OHIO STATE UNIVERSITY · PI KITZMILLER, JOSEPH PAUL · 2011 to 2015
$955k
NIGMS NIH HHS K23 GM100372
6 · The paper itself

Abstract

Clinicians and patients continue to convey interest in personalized medicine. The objective of personalized medicine is to improve healthcare by tailoring disease prevention, diagnosis, and treatment strategies for individuals based on their unique clinical history and genetic composition. This article offers an overview of pharmacogenomics, discusses caveats specific to pharmacogenomics in pediatric populations, provides evidence-based recommendations for pediatric clinicians, and offers insight regarding the future role of pharmacogenomics testing in pediatric medicine. Reviews of the current literature and thoughtful discussions are presented regarding the pharmacogenomics of antidepressants, codeine and oncologic, asthma, and immunomodulatory pharmacotherapies.

Indexed as

PharmacogeneticsAntidepressive AgentsAsthmaChildCodeineCytochrome P-450 CYP2D6HumansImmunologic FactorsMercaptopurineMethotrexatePediatricsPolymorphism, Single NucleotideTacrolimusAntidepressive AgentsCodeineCytochrome P-450 CYP2D6Immunologic FactorsMercaptopurineMethotrexateTacrolimusgeneticspediatricspharmacogenomicspharmacotherapy

Identifiers

PMID24803633
PMCPMC4222996
OpenAlexW2129348030

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.