ArticleMagnetic resonance in medicine2015
Observation of true and pseudo NOE signals using CEST-MRI and CEST-MRS sequences with and without lipid suppression.
Article in Magnetic resonance in medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 52 citations in OpenAlex.
- Toward Free-Breathing Renal CEST MRI: Preclinical Evaluation of a Novel Prospective Respiratory Triggering Approach.Magnetic resonance in medicine · 2026Article
- Characterizing Metabolic and Compositional Heterogeneity of Calf Muscle Using CEST MRI at 3 T.NMR in biomedicine · 2026Article
- Fat/Water Separation at 7 T Using a 3D Radial Sequence With Quasi-Continuous Echo Times.Magnetic resonance in medicine · 2026Article
- Denoising Low-Power CEST Imaging Using a Deep Learning Approach With a Dual-Power Feature Preparation Strategy.Magnetic resonance in medicine · 2026Article
- Chemical Exchange Saturation Transfer Imaging in Neuroinflammation: Methods, Challenges, and Recommendations.International journal of molecular sciences · 2025Review
- Parameter optimization for proton density fat fraction quantification in skeletal muscle tissue at 7 T.Magma (New York, N.Y.) · 2024Article
- Development and Validation of Four Different Methods to Improve MRI-CEST Tumor pH Mapping in Presence of Fat.Journal of imaging · 2024Article
- An update on liver chemical exchange saturation transfer imaging with a focus on clinical translation.Quantitative imaging in medicine and surgery · 2023Article
- Saturation transfer MRI is sensitive to neurochemical changes in the rat brain due to chronic unpredictable mild stress.Scientific reports · 2021Article
- Combining chemical exchange saturation transfer andMagnetic resonance in medicine · 2021Article
- Effectiveness of fat suppression using a water-selective binomial-pulse excitation in chemical exchange saturation transfer (CEST) magnetic resonance imaging.Magma (New York, N.Y.) · 2020Article
- CEST MRI quantification procedures for breast cancer treatment-related lymphedema therapy evaluation.Magnetic resonance in medicine · 2020Article
- APT-weighted MRI: Techniques, current neuro applications, and challenging issues.Journal of magnetic resonance imaging : JMRI · 2019Review
- Improving the detection specificity of endogenous MRI for reactive oxygen species (ROS).Journal of magnetic resonance imaging : JMRI · 2019Article
- Influences of experimental parameters on chemical exchange saturation transfer (CEST) metrics of brain tumors using animal models at 4.7T.Magnetic resonance in medicine · 2019Article
- Brain investigations of rodent disease models by chemical exchange saturation transfer at 21.1 T.NMR in biomedicine · 2018Article
- CEST-Dixon for human breast lesion characterization at 3 T: A preliminary study.Magnetic resonance in medicine · 2018Article
- Z-spectrum appearance and interpretation in the presence of fat: Influence of acquisition parameters.Magnetic resonance in medicine · 2018Article
- Amide proton transfer CEST of the cervical spinal cord in multiple sclerosis patients at 3T.Magnetic resonance in medicine · 2018Article
- MR imaging of a novel NOE-mediated magnetization transfer with water in rat brain at 9.4 T.Magnetic resonance in medicine · 2017Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
purposeTo investigate the characteristics of nuclear Overhauser enhancement (NOE) imaging signals in the brain at 7T.
methodsFresh hen eggs, as well as six healthy, and six C6 glioma-bearing Wistar rats were scanned using chemical exchange saturation transfer-magnetic resonance imaging (CEST-MRI) and chemical exchange saturation transfer-magnetic resonance spectroscopy (CEST-MRS) sequences (saturation duration 3 s, power 1.47 µT) with and without lipid suppression. CEST data were acquired over an offset range of -6 to +6 ppm relative to the water resonance in 0.5 ppm steps.
resultsThe water signals were not disrupted by other protons during the CEST-MRS sequences, and true NOE signals could be observed. Using the CEST-MRI sequence without lipid suppression, pseudo NOE imaging signals were observed in the lipid-containing regions (egg yolk, scalp, and even white matter). These pseudo NOE signals were almost (but incompletely) removed with the lipid suppression. Egg yolk results indicated the presence of the NOE to olefinic protons overlapping with the water signal. In vivo experiments showed that the amide proton transfer signal was larger in the tumor, whereas the NOE signal was larger in the normal white matter.
conclusionsTrue NOE signals can be detected using MRS sequences, and considerable pseudo NOE imaging signals may be observed using MRI sequences.
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