ArticleBlood2014
Mapping hematopoiesis in a fully regenerative vertebrate: the axolotl.
Article in Blood, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 60 citations in OpenAlex.
- Are axolotls resistant to cancer? Possible explanations.Molecular biology reports · 2026Review
- An Amphibians-Derived Protein Provides Novel Biotherapeutics for Various Wounds Treatment.Biomolecules & therapeutics · 2025Article
- The salamander limb: a perfect model to understand imperfect integration during skeletal regeneration.Biology open · 2024Review
- The amphibian immune system.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- Structural and functional analysis of the newt lymphatic system.Scientific reports · 2023Article
- Characterization of immunoglobulinFrontiers in immunology · 2023Article
- Salamanders as Key Models for Development and Regeneration Research.Methods in molecular biology (Clifton, N.J.) · 2023Review
- The specialist in regeneration-the Axolotl-a suitable model to study bone healing?NPJ Regenerative medicine · 2022Article
- Distinct toll-like receptor signaling in the salamander response to tissue damage.Developmental dynamics : an official publication of the American Association of Anatomists · 2022Article
- Immune cells in cardiac repair and regeneration.Development (Cambridge, England) · 2022Review
- The Axolotl's journey to the modern molecular era.Current topics in developmental biology · 2022Article
- Germline competent mesoderm: the substrate for vertebrate germline and somatic stem cells?Biology open · 2021Article
- Article
- Immunity in salamander regeneration: Where are we standing and where are we headed?Developmental dynamics : an official publication of the American Association of Anatomists · 2021Review
- Salamander Insights Into Ageing and Rejuvenation.Frontiers in cell and developmental biology · 2021Article
- Identification of the Adult Hematopoietic Liver as the Primary Reservoir for the Recruitment of Pro-regenerative Macrophages Required for Salamander Limb Regeneration.Frontiers in cell and developmental biology · 2021Article
- Review
- Parallels between wound healing, epimorphic regeneration and solid tumors.Development (Cambridge, England) · 2020Review
- Hematopoiesis: A Layered Organization Across Chordate Species.Frontiers in cell and developmental biology · 2020Review
- Meningeal Foam Cells and Ependymal Cells in Axolotl Spinal Cord Regeneration.Frontiers in immunology · 2019Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Hematopoietic stem cell (HSC)-derived cells are involved in wound healing responses throughout the body. Unfortunately for mammals, wound repair typically results in scarring and nonfunctional reparation. Among vertebrates, none display such an extensive ability for adult regeneration as urodele amphibians, including 1 of the more popular models: the axolotl. However, a lack of knowledge of axolotl hematopoiesis hinders the use of this animal for the study of hematopoietic cells in scar-free wound healing and tissue regeneration. We used white and cytomegalovirus:green fluorescent protein(+) transgenic white axolotl strains to map sites of hematopoiesis and develop hematopoietic cell transplant methodology. We also established a fluorescence-activated cell sorter enrichment technique for major blood lineages and colony-forming unit assays for hematopoietic progenitors. The liver and spleen are both active sites of hematopoiesis in adult axolotls and contain transplantable HSCs capable of long-term multilineage blood reconstitution. As in zebrafish, use of the white axolotl mutant allows direct visualization of homing, engraftment, and hematopoiesis in real time. Donor-derived hematopoiesis occurred for >2 years in recipients generating stable hematopoietic chimeras. Organ segregation, made possible by embryonic microsurgeries wherein halves of 2 differently colored embryos were joined, indicate that the spleen is the definitive site of adult hematopoiesis.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.