ReviewJournal of proteomics2014
A new class of protein cancer biomarker candidates: differentially expressed splice variants of ERBB2 (HER2/neu) and ERBB1 (EGFR) in breast cancer cell lines.
Review in Journal of proteomics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 42 citations in OpenAlex.
- Antitumor Activities of Aqueous Cinnamon Extract on 5637 Cell Line of Bladder Cancer through Glycolytic Pathway.International journal of inflammation · 2022Article
- Survival-associated alternative splicing events interact with the immune microenvironment in stomach adenocarcinoma.World journal of gastroenterology · 2021Article
- TSVdb: a web-tool for TCGA splicing variants analysis.BMC genomics · 2018Article
- Exploiting differential RNA splicing patterns: a potential new group of therapeutic targets in cancer.Expert opinion on therapeutic targets · 2018Review
- Discovery of new candidate genes for rheumatoid arthritis through integration of genetic association data with expression pathway analysis.Arthritis research & therapy · 2017Article
- Gene markers of fracture healing in early stage and the regulatory mechanism during the process using microarray analysis.Acta orthopaedica et traumatologica turcica · 2016Article
- A proteogenomic approach to understand splice isoform functions through sequence and expression-based computational modeling.Briefings in bioinformatics · 2016Article
- Exploring the intrinsic differences among breast tumor subtypes defined using immunohistochemistry markers based on the decision tree.Scientific reports · 2016Article
- Determining breast cancer histological grade from RNA-sequencing data.Breast cancer research : BCR · 2016Article
- HER2/ERBB2 immunoreactivity in human retinoblastoma.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- A Network of Splice Isoforms for the Mouse.Scientific reports · 2016Article
- Functional Networks of Highest-Connected Splice Isoforms: From The Chromosome 17 Human Proteome Project.Journal of proteome research · 2015Article
- MI-PVT: A Tool for Visualizing the Chromosome-Centric Human Proteome.Journal of proteome research · 2015Article
- Rare coding mutations identified by sequencing of Alzheimer disease genome-wide association studies loci.Annals of neurology · 2015Article
- Genes Caught In Flagranti: Integrating Renal Transcriptional Profiles With Genotypes and Phenotypes.Seminars in nephrology · 2015Review
- MIsoMine: a genome-scale high-resolution data portal of expression, function and networks at the splice isoform level in the mouse.Database : the journal of biological databases and curation · 2015Article
- Revisiting the identification of canonical splice isoforms through integration of functional genomics and proteomics evidence.Proteomics · 2014Article
- The emerging era of genomic data integration for analyzing splice isoform function.Trends in genetics : TIG · 2014Review
- Wrecked regulation of intrinsically disordered proteins in diseases: pathogenicity of deregulated regulators.Frontiers in molecular biosciences · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Combined RNA-Seq and proteomics analyses reveal striking differential expression of splice isoforms of key proteins in important cancer pathways and networks. Even between primary tumor cell lines from histologically similar inflammatory breast cancers, we find striking differences in hormone receptor-negative cell lines that are ERBB2 (Her2/neu)-amplified versus ERBB1 (EGFR) over-expressed with low ERBB2 activity. We have related these findings to protein-protein interaction networks, signaling and metabolic pathways, and methods for predicting functional variants among multiple alternative isoforms. Understanding the upstream ligands and regulators and the downstream pathways and interaction networks for ERBB receptors is certain to be important for explanation and prediction of the variable levels of expression and therapeutic responses of ERBB+tumors in the breast and in other organ sites. Alternative splicing is a remarkable evolutionary development that increases protein diversity from multi-exonic genes without requiring expansion of the genome. It is no longer sufficient to report the up- or down-expression of genes and proteins without dissecting the complexity due to alternative splicing. This article is part of a Special Issue entitled: 20Years of Proteomics in memory of Viatliano Pallini. Guest Editors: Luca Bini , Juan J. Calvete, Natacha Turck, Denis Hochstrasser and Jean-Charles Sanchez.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.