ArticleCell cycle (Georgetown, Tex.)2014
Inhibition of Polo kinase by BI2536 affects centriole separation during Drosophila male meiosis.
Article in Cell cycle (Georgetown, Tex.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 19 citations in OpenAlex.
- Review
- Ana1 helps recruit Polo to centrioles to promote mitotic PCM assembly and centriole elongation.Journal of cell science · 2021Article
- Centrioles and Ciliary Structures during Male Gametogenesis in Hexapoda: Discovery of New Models.Cells · 2020Review
- TheCells · 2020Article
- Article
- An ordered pattern of Ana2 phosphorylation by Plk4 is required for centriole assembly.The Journal of cell biology · 2018Article
- Polo-like kinase 1 coordinates biosynthesis during cell cycle progression by directly activating pentose phosphate pathway.Nature communications · 2017Article
- The Centrioles, Centrosomes, Basal Bodies, and Cilia ofGenetics · 2017Review
- Klp10A modulates the localization of centriole-associated proteins during Drosophila male gametogenesis.Cell cycle (Georgetown, Tex.) · 2016Article
- Myt1 inhibition of Cyclin A/Cdk1 is essential for fusome integrity and premeiotic centriole engagement in Drosophila spermatocytes.Molecular biology of the cell · 2016Article
- Loss of Polo ameliorates APP-induced Alzheimer's disease-like symptoms in Drosophila.Scientific reports · 2015Article
- Aurora A inhibition by MNL8054 promotes centriole elongation during Drosophila male meiosis.Cell cycle (Georgetown, Tex.) · 2015Article
- Plk4 phosphorylates Ana2 to trigger Sas6 recruitment and procentriole formation.Current biology : CB · 2014Article
- Polo kinase regulates the localization and activity of the chromosomal passenger complex in meiosis and mitosis in Drosophila melanogaster.Open biology · 2014Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 3 countries.
Funding
Abstract
Pharmacological inhibition of Drosophila Polo kinase with BI2536 has allowed us to re-examine the requirements for Polo during Drosophila male gametogenesis. BI2536-treated spermatocytes persisted in a pro-metaphase state without dividing and had condensed chromosomes that did not separate. Centrosomes failed to recruit γ-tubulin and centrosomin (Cnn) and were not associated with microtubule arrays that were abnormal and did not form proper bipolar spindles. Centrioles, which usually separate during the anaphase of the first meiosis, remained held together in a V-shaped configuration suggesting that Polo kinase regulates the proteolysis that breaks centriole linkage to ensure their disengagement. Despite these defects spermatid differentiation proceeds, leading to axoneme formation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.