ArticlePloS one2014
Prenatal origins of temperament: fetal growth, brain structure, and inhibitory control in adolescence.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Trajectories of brain and behaviour development in the womb, at birth and through infancy.Nature human behaviour · 2024Review
- Birth weight rather than birth length is associated with childhood behavioural problems in a Czech ELSPAC cohort.PloS one · 2021Article
- Birth weight is associated with adolescent brain development: A multimodal imaging study in monozygotic twins.Human brain mapping · 2020Article
- Effects of maternal stress and nutrient restriction during gestation on offspring neuroanatomy in humans.Neuroscience and biobehavioral reviews · 2020Review
- Non-reassuring foetal status and neonatal irritability in the Japan Environment and Children's Study: A cohort study.Scientific reports · 2018Article
- Prenatal and early postnatal measures of brain development and childhood sleep patterns.Pediatric research · 2018Article
- Birth weight discordance, DNA methylation, and cortical morphology of adolescent monozygotic twins.Human brain mapping · 2017Article
- Neonatal neural networks predict children behavioral profiles later in life.Human brain mapping · 2017Article
- Being Small for Gestational Age: Does it Matter for the Neurodevelopment of Premature Infants? A Cohort Study.PloS one · 2015Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
objectiveIndividual differences in the temperamental dimension of effortful control are constitutionally based and have been associated with an adverse prenatal developmental environment, with structural brain alterations presenting a potential mechanism. We investigated this hypothesis for anatomically defined brain regions implicated in cognitive and inhibitory motor control.
methodsTwenty-seven 15-16 year old participants with low, medium, or high fetal growth were selected from a longitudinal birth cohort to maximize variation and represent the full normal spectrum of fetal growth. Outcome measures were parent ratings of attention and inhibitory control, thickness and surface area of the orbitofrontal cortex (lateral (LOFC) and medial (MOFC)) and right inferior frontal gyrus (rIFG), and volumetric measures of the striatum and amygdala.
resultsLower birth weight was associated with lower inhibitory control, smaller surface area of LOFC, MOFC and rIFG, lower caudate volume, and thicker MOFC. A mediation model found a significant indirect effect of birth weight on inhibitory control via caudate volume.
conclusionsOur findings support a neuroanatomical mechanism underlying potential long-term consequences of an adverse fetal developmental environment for behavioral inhibitory control in adolescence and have implications for understanding putative prenatal developmental origins of externalizing behavioral problems and self-control.
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