ArticleJournal of exposure science & environmental epidemiology2015
Persistent organic pollutants (POPs) and fibroids: results from the ENDO study.
Article in Journal of exposure science & environmental epidemiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 49 citations in OpenAlex.
- An Epidemiologic Review of Endocrine-disrupting Chemicals and Understudied Gynecologic Health Conditions Affecting Quality of Life.Current environmental health reports · 2026Review
- Associations of per- and polyfluoroalkyl substances with uterine leiomyomata incidence and growth: a prospective ultrasound study.Journal of exposure science & environmental epidemiology · 2025Article
- Association between combined exposure to organochlorine pesticides and history of uterine fibroids in NHANES: findings from four statistical models.BMC public health · 2025Article
- Persistent endocrine-disrupting chemicals and incident uterine leiomyomata: A mixtures analysis.The Science of the total environment · 2024Article
- Environmental Exposure to Persistent Organic Pollutants and Its Association with Endometriosis Risk: Implications in the Epithelial-Mesenchymal Transition Process.International journal of molecular sciences · 2024Article
- Update of the risk assessment of polybrominated diphenyl ethers (PBDEs) in food.EFSA journal. European Food Safety Authority · 2024Article
- Associations of Pregnancy Per- and Polyfluoroalkyl Substance Concentrations and Uterine Fibroid Changes across Pregnancy: NICHD Fetal Growth Studies - Singletons Cohort.Environmental health perspectives · 2023Article
- Fruit and vegetable consumption, pesticide residue intake from consumption of fruits and vegetables, and risk of uterine fibroids.F&S science · 2023Article
- Article
- Uncovering Evidence: Associations between Environmental Contaminants and Disparities in Women's Health.International journal of environmental research and public health · 2022Review
- Polybrominated diphenyl ethers in the environment: a wake-up call for concerted action in India.Environmental science and pollution research international · 2021Review
- A Prospective Ultrasound Study of Plasma Polychlorinated Biphenyl Concentrations and Incidence of Uterine Leiomyomata.Epidemiology (Cambridge, Mass.) · 2021Article
- Brominated flame retardants and organochlorine pesticides and incidence of uterine leiomyomata: A prospective ultrasound study.Environmental epidemiology (Philadelphia, Pa.) · 2021Article
- Environmental Factors Involved in Maternal Morbidity and Mortality.Journal of women's health (2002) · 2021Article
- Endocrine disrupting chemicals and reproductive disorders in women, men, and animal models.Advances in pharmacology (San Diego, Calif.) · 2021Article
- The Potential Relationship Between Environmental Endocrine Disruptor Exposure and the Development of Endometriosis and Adenomyosis.Frontiers in physiology · 2021Review
- Dietary Fat Intake and Risk of Uterine Leiomyomata: A Prospective Ultrasound Study.American journal of epidemiology · 2020Article
- Correlates of organochlorine pesticide plasma concentrations among reproductive-aged black women.Environmental research · 2020Article
- Persistent environmental endocrine-disrupting chemicals in ovarian follicular fluid andUpsala journal of medical sciences · 2020Review
- microRNA-371a-3p as informative biomarker for the follow-up of testicular germ cell cancer patients.Cellular oncology (Dordrecht, Netherlands) · 2017Article
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
To evaluate the association between persistent organic pollutants (POPs) and uterine fibroids, we used previously collected data from a cohort of women aged 18-44 years undergoing laparoscopy or laparotomy at 14 participating hospital surgical centers (n=473). POP concentrations were measured in omental fat and serum. Presence of fibroids was defined on the basis of a postoperative diagnosis (n=99). Odds ratios (OR) and 95% confidence interval (CI) for each POP by biologic medium were estimated using unconditional logistic regression adjusted for identified covariates. Concentrations were higher in omental fat than in serum for all POPs. Serum p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE) was the only POP associated with fibroids (per 1-SD increase in log-transformed p,p'-DDE OR (95% CI): 1.37 (1.05-1.80)). In analyses excluding women diagnosed with endometriosis, a number of polychlorinated biphenyls (PCBs) measured in omental fat were associated with fibroids (PCB 99: 1.64 (1.08, 2.49); PCB 138: 1.64 (1.03, 2.59); PCB 146: 1.54 (1.01, 2.37); PCB 153: 1.88 (1.12, 3.13); PCB 196: 1.60 (1.02, 2.51); PCB 206: 1.52 (1.01, 2.29)). Although exploratory, our study suggests that PCBs may be associated with fibroids in the absence of other gynecologic disorders such as endometriosis, but the associations varied by biologic media with more POPs emerging when quantified in fat.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.