ArticleEuropean journal of nuclear medicine and molecular imaging2014
Role of ¹⁸F-FDG PET/CT in the diagnosis of infective endocarditis in patients with an implanted cardiac device: a prospective study.
Article in European journal of nuclear medicine and molecular imaging, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
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Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 82 citations in OpenAlex.
- Meta-analysis of 18F-FDG PET/CT in the diagnosis of infective endocarditis.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019Pooled it
- Role ofJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019Pooled it
- Assessment of the diagnostic accuracy ofEuropean journal of nuclear medicine and molecular imaging · 2016Trial
- Hyper-rapid progression in Salmonella-associated mycotic aortic aneurysms: a narrative review.Radiology and oncology · 2026Review
- Gram-Negative Bacterial Infections in Cardiac Implantable Electronic Devices: Insights from a Retrospective Analysis of Multidrug-Resistant and Non-Multidrug-Resistant Isolates.Pathogens (Basel, Switzerland) · 2025Observational
- Innovations in Imaging:Current cardiology reports · 2024Review
- Risk of Cardiac Implantable Electronic Device Infection in Patients with Bloodstream Infection: Microbiologic Effect in the Era of Positron Emission Tomography-Computed Tomography.Current cardiology reports · 2023Review
- Is Imaging Bacteria with PET a Realistic Option or an Illusion?Diagnostics (Basel, Switzerland) · 2023Review
- Cardiovascular positron emission tomography: established and emerging role in cardiovascular diseases.Heart failure reviews · 2023Review
- Advances in Molecular Imaging in Infective Endocarditis.Vaccines · 2023Review
- Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
- Accuracy ofJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
- Nuclear Imaging in Infective Endocarditis.Pharmaceuticals (Basel, Switzerland) · 2021Review
- The Diagnostic Value of 99mTc-HMPAO-Labelled White Blood Cell Scintigraphy and 18F-FDG PET/CT in Cardiac Device-Related Infective Endocarditis-A Systematic Review.Journal of personalized medicine · 2021Review
- Procedural recommendations of cardiac PET/CT imaging: standardization in inflammatory-, infective-, infiltrative-, and innervation (4Is)-related cardiovascular diseases: a joint collaboration of the EACVI and the EANM.European journal of nuclear medicine and molecular imaging · 2021Article
- Cardiac Sarcoidosis Mimicking Anterior Myocardial Infarction.Annals of nuclear cardiology · 2021Article
- Procedural recommendations of cardiac PET/CT imaging: standardization in inflammatory-, infective-, infiltrative-, and innervation- (4Is) related cardiovascular diseases: a joint collaboration of the EACVI and the EANM: summary.European heart journal. Cardiovascular Imaging · 2020Article
- Usefulness ofJournal of clinical medicine · 2020Article
- Multimodality Imaging in the Diagnostic Work-Up of Endocarditis and Cardiac Implantable Electronic Device (CIED) Infection.Journal of clinical medicine · 2020Review
- Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019Article
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Authors and funding
15 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeInfective endocarditis (IE) is widely underdiagnosed or diagnosed after a major delay. The diagnosis is currently based on the modified DUKE criteria, where the only validated imaging technique is echocardiography, and remains challenging especially in patients with an implantable cardiac device. The aim of this study was to assess the incremental diagnostic role of (18)F-FDG PET/CT in patients with an implanted cardiac device and suspected IE.
methodsWe prospectively analysed 27 consecutive patients with an implantable device evaluated for suspected device-related IE between January 2011 and June 2013. The diagnostic probability of IE was defined at presentation according to the modified DUKE criteria. PET/CT was performed as soon as possible following the clinical suspicion of IE. Patients then underwent medical or surgical treatment based on the overall clinical evaluation. During follow-up, we considered: lead cultures in patients who underwent extraction, direct inspection and lead cultures in those who underwent surgery, and a clinical/instrumental reevaluation after at least 6 months in patients who received antimicrobial treatment or had an alternative diagnosis and were not treated for IE. After the follow-up period, the diagnosis was systematically reviewed by the multidisciplinary team using the modified DUKE criteria and considering the new findings.
resultsAmong the ten patients with a positive PET/CT scan, seven received a final diagnosis of "definite IE", one of "possible IE" and two of "IE rejected". Among the 17 patients with a negative PET/CT scan, four were false-negative and received a final diagnosis of definite IE. These patients underwent PET/CT after having started antibiotic therapy (≥48 h) or had a technically suboptimal examination.
conclusionIn patients with a cardiac device, PET/CT increases the diagnostic accuracy of the modified Duke criteria for IE, particularly in the subset of patients with possible IE in whom it may help the clinician manage a challenging situation.
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