ArticleJournal of neural transmission (Vienna, Austria : 1996)2014
Protein S-100 and neuron-specific enolase serum levels remain unaffected by electroconvulsive therapy in patients with depression.
Article in Journal of neural transmission (Vienna, Austria : 1996), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03040388 (Predicting Effects and Risk of Relapse Into Depression - The Danish ECT/MRI Project), which is not on this map. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Predicting Effects and Risk of Relapse Into Depression - The Danish ECT/MRI Project
Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Effects of electroconvulsive therapy on cortical thickness in depression: a systematic review.Acta neuropsychiatrica · 2024Pooled it
- The use of functional near-infrared spectroscopy (fNIRS) as a potential marker of the efficacy and safety of electroconvulsive therapy.Postepy psychiatrii neurologii · 2025Review
- Blood biomarkers of neuronal injury and astrocytic reactivity in electroconvulsive therapy.Molecular psychiatry · 2025Article
- The myth of brain damage: no change of neurofilament light chain during transient cognitive side-effects of ECT.European archives of psychiatry and clinical neuroscience · 2024Article
- Blood-brain barrier permeability and electroconvulsive therapy: a systematic review.Acta neuropsychiatrica · 2023Review
- Peripheral S100B Protein Levels in Five Major Psychiatric Disorders: A Systematic Review.Brain sciences · 2023Review
- High S100B Levels Predict Antidepressant Response in Patients With Major Depression Even When Considering Inflammatory and Metabolic Markers.The international journal of neuropsychopharmacology · 2022Article
- The Neurobiological Basis of Cognitive Side Effects of Electroconvulsive Therapy: A Systematic Review.Brain sciences · 2021Review
- S100B, Homocysteine, Vitamin B12, Folic Acid, and Procalcitonin Serum Levels in Remitters to Electroconvulsive Therapy: A Pilot Study.Disease markers · 2018Article
- Potential Mechanisms Underlying the Therapeutic Effects of Electroconvulsive Therapy.Neuroscience bulletin · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mechanism of the reversible cognitive deficits that might occur within an electroconvulsive therapy (ECT) treatment has not been clarified in a substantial way yet. Although the data available so far do not point towards a cause due to any structural or diffuse damage, further clarification, especially of the role of S-100 seems to be necessary before robust conclusions can be drawn. Serum levels of protein S-100 and neuron-specific enolase (NSE) were analysed in 19 patients with depression, who received ECT. The sampling was adjusted for the short half-life of protein S-100. Several outcome parameters such as Hamilton Depression Rating Scale and Mini-mental state examination before and after the ECT, response and remission to the treatment were recorded. S-100 and NSE levels at baseline, 30 and 60 min after the third session and after the end of the ECT remained stable. S-100 and NSE levels were neither associated with antidepressant response or remission nor with alterations in the cognitive performance. Although aiming for detecting potential rise in these established brain damage markers, an increase due to ECT was not observed, which is in line with the previous studies concerning the safety of ECT on a cellular basis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.