ArticleViral immunology2014
Differential induction of cytokines by human neonatal, adult, and elderly monocyte/macrophages infected with dengue virus.
Article in Viral immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 33 citations in OpenAlex.
- Dengue virus infection: how platelet-leukocyte crosstalk shapes thrombotic events and inflammation.Molecular biology reports · 2025Review
- Spatiotemporal dispersion of DENV-1 genotype V in Western Colombia.Virus evolution · 2025Article
- Protective immune response induced by Leghorn male hepatoma cell-adapted fowl adenovirus-4.Heliyon · 2024Article
- Angiotensin II and dengue.Archives of virology · 2023Review
- Clinical profile of dengue in the elderly using surveillance data from two epidemics.Revista da Sociedade Brasileira de Medicina Tropical · 2022Article
- Dengue virus replication enhances labile zinc pools by modulation of ZIP8.Cellular microbiology · 2021Article
- Emergence of Dengue 4 as Dominant Serotype During 2017 Outbreak in South India and Associated Cytokine Expression Profile.Frontiers in cellular and infection microbiology · 2021Article
- Overcoming immune dysfunction in the elderly: trained immunity as a novel approach.International immunology · 2020Review
- Crocetin Improves Dengue Virus-Induced Liver Injury.Viruses · 2020Article
- Atypical Presentation of Methicillin-SusceptiblePathogens (Basel, Switzerland) · 2020Article
- Impaired functional capacity of polarised neonatal macrophages.Scientific reports · 2020Article
- Age-Dependent Changes of Adipokine and Cytokine Secretion From Rat Adipose Tissue by Endogenous and Exogenous Toll-Like Receptor Agonists.Frontiers in immunology · 2020Article
- Inflammasome Fuels Dengue Severity.Frontiers in cellular and infection microbiology · 2020Review
- Severe Fever With Thrombocytopenia Syndrome Virus-Induced Macrophage Differentiation Is Regulated by miR-146.Frontiers in immunology · 2019Article
- Intrinsic Maturational Neonatal Immune Deficiencies and Susceptibility to Group B Streptococcus Infection.Clinical microbiology reviews · 2017Review
- Article
- The Cellular Bases of Antibody Responses during Dengue Virus Infection.Frontiers in immunology · 2016Review
- Age-dependent variation in innate immune responses to porcine epidemic diarrhea virus infection in suckling versus weaned pigs.Veterinary immunology and immunopathology · 2015Article
- Carica papaya induces in vitro thrombopoietic cytokines secretion by mesenchymal stem cells and haematopoietic cells.BMC complementary and alternative medicine · 2015Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Immunosuppressive status against infections in monocytes from neonates and elderly subjects has been reported. The interaction between dengue virus and monocytes/macrophages plays an important role during dengue disease. The aim of this study was to determine the cytokine response of monocytes from individuals with different ages after infection with dengue virus. Monocyte/macrophage cultures from neonatal, adult, and elderly subjects (n=10 each group) were incubated with all four dengue virus types (DENV-1 to -4). After 1 and 3 days of culture, cytokine concentrations (TNF-α, IL-6, and IL-1β) were determined in culture supernatants by enzyme-linked immunosorbant assay. Increased production of all studied cytokines was induced by the different viral types in monocyte/macrophage cultures regardless of their source. However, lower cytokine concentrations were found in neonatal and elderly monocytes. The relative monocyte/macrophage immunosuppressive status observed in neonates and the elderly could be relevant during dengue infection in those age groups and important in innate and adaptive immunity responses against this virus.
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