ArticleDiabetes technology & therapeutics2014
Feasibility study of a bio-inspired artificial pancreas in adults with type 1 diabetes.
Article in Diabetes technology & therapeutics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
- Outpatient Closed-Loop Control with Unannounced Moderate Exercise in Adolescents Using Zone Model Predictive Control.Diabetes technology & therapeutics · 2017Trial
- Metabolic Control With the Bio-inspired Artificial Pancreas in Adults With Type 1 Diabetes: A 24-Hour Randomized Controlled Crossover Study.Journal of diabetes science and technology · 2015Trial
- The 'Designer' Artificial Pancreas: How Does Current Technology Mimic Pancreatic Physiology?Cureus · 2025Review
- Correction of T-Cell Repertoire and Autoimmune Diabetes in NOD Mice by Non-myeloablative T-Cell Depleted Allogeneic HSCT.Stem cells translational medicine · 2023Article
- A Comprehensive Review of the Evolution of Insulin Development and Its Delivery Method.Pharmaceutics · 2022Review
- An In Silico Head-to-Head Comparison of the Do-It-Yourself Artificial Pancreas Loop and Bio-Inspired Artificial Pancreas Control Algorithms.Journal of diabetes science and technology · 2022Article
- The Bio-inspired Artificial Pancreas for Type 1 Diabetes Control in the Home: System Architecture and Preliminary Results.Journal of diabetes science and technology · 2019Article
- Diabetes Technology: Monitoring, Analytics, and Optimal Control.Cold Spring Harbor perspectives in medicine · 2019Review
- Modeling the effect of the cephalic phase of insulin secretion on glucose metabolism.Medical & biological engineering & computing · 2019Article
- Optimal regulation of blood glucose level in Type I diabetes using insulin and glucagon.PloS one · 2019Article
- Automated closed-loop control of diabetes: the artificial pancreas.Bioelectronic medicine · 2018Review
- A coordinated control strategy for insulin and glucagon delivery in type 1 diabetes.Computer methods in biomechanics and biomedical engineering · 2017Article
- Enhancing automatic closed-loop glucose control in type 1 diabetes with an adaptive meal bolus calculator - in silico evaluation under intra-day variability.Computer methods and programs in biomedicine · 2017Article
- A Review of the Current Challenges Associated with the Development of an Artificial Pancreas by a Double Subcutaneous Approach.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2017Review
- A Review of Safety and Design Requirements of the Artificial Pancreas.Annals of biomedical engineering · 2016Review
- Artificial Pancreas Device Systems for the Closed-Loop Control of Type 1 Diabetes: What Systems Are in Development?Journal of diabetes science and technology · 2016Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThis study assesses proof of concept and safety of a novel bio-inspired artificial pancreas (BiAP) system in adults with type 1 diabetes during fasting, overnight, and postprandial conditions. In contrast to existing glucose controllers in artificial pancreas systems, the BiAP uses a control algorithm based on a mathematical model of β-cell physiology. The algorithm is implemented on a miniature silicon microchip within a portable hand-held device that interfaces the components of the artificial pancreas. MATERIALS AND
methodsIn this nonrandomized open-label study each subject attended for a 6-h fasting study followed by a 13-h overnight and post-breakfast study on a separate occasion. During both study sessions the BiAP system was used, and microboluses of insulin were recommended every 5 min by the control algorithm according to subcutaneous sensor glucose levels. The primary outcome was percentage time spent in the glucose target range (3.9-10.0 mmol/L).
resultsTwenty subjects (55% male; mean [SD] age, 44 [10] years; duration of diabetes, 22 [12] years; glycosylated hemoglobin, 7.4% [0.7%] [57 (7) mmol/mol]; body mass index, 25 [4] kg/m(2)) participated in the fasting study, and the median (interquartile range) percentage time in target range was 98.0% (90.8-100.0%). Seventeen of these subjects then participated in the overnight/postprandial study, where 70.7% (63.9-77.4%) of time was spent in the target range and, reassuringly, 0.0% (0.0-2.3%) of time was spent in hypoglycemia (<3.9 mmol/L).
conclusionsThe BiAP achieves safe glycemic control during fasting, overnight, and postprandial conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.