SynthesisJournal of thrombosis and haemostasis : JTH2014
Central venous catheter-related thrombosis and thromboprophylaxis in children: a systematic review and meta-analysis.
Synthesis in Journal of thrombosis and haemostasis : JTH, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 5 syntheses or guidelines pooled it, 135 citations in OpenAlex.
- American Society of Hematology/International Society on Thrombosis and Haemostasis 2024 updated guidelines for treatment of venous thromboembolism in pediatric patients.Blood advances · 2025Guideline
- Epidemiology and risk factors for thrombosis in children and newborns: systematic evaluation and meta-analysis.BMC pediatrics · 2023Pooled it
- Low molecular weight heparin for prevention of central venous catheter-related thrombosis in children.The Cochrane database of systematic reviews · 2020Pooled it
- Epidemiology and outcomes of clinically unsuspected venous thromboembolism in children: A systematic review.Journal of thrombosis and haemostasis : JTH · 2020Pooled it
- Association of thrombophilia and catheter-associated thrombosis in children: a systematic review and meta-analysis.Journal of thrombosis and haemostasis : JTH · 2016Pooled it
- Effect of impregnated central venous catheters on thrombosis in paediatric intensive care: Post-hoc analyses of the CATCH trial.PloS one · 2019Trial
- Diagnostic accuracy of point-of-care ultrasound for catheter-related thrombosis in children.Pediatric radiology · 2016Trial
- Article
- Looking Beyond Line Placement: Central Venous Catheter-Related Thrombosis in PICU.Indian pediatrics · 2026Article
- Article
- Neonatal epicutaneo-cava catheter-related thrombosis: a comprehensive overview.Thrombosis journal · 2026Review
- Central Venous Catheter-Related Thrombosis in Critically Ill Children: Diagnostic Characteristics, Therapeutic Approaches, and Preliminary Outcomes.Indian journal of pediatrics · 2026Article
- Two threats in early life: congenital hyperinsulinemic hypoglycemia and thrombosis.Therapeutic advances in endocrinology and metabolism · 2026Article
- Article
- Managing Multifactorial Deep Vein Thrombosis in an Adolescent: A Complex Case Report.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2024Article
- Case Report: Vascular access in paediatric haemodialysis patients-creating and maintaining the patency of an arteriovenous fistula.Frontiers in surgery · 2024Article
- Evaluation of non-infectious complications in children receiving parenteral nutrition.Irish journal of medical science · 2023Article
- Complications Associated with Subsequent Vascular Access in Pediatric ECMO Patients.Journal of pediatric surgery · 2023Article
- Thromboprophylaxis for children hospitalized with COVID-19 and MIS-C.Research and practice in thrombosis and haemostasis · 2022Article
- Management of Central Venous Catheters in Children and Adults on Home Parenteral Nutrition: A French Survey of Current Practice.Nutrients · 2022Article
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 1 country.
Funding
Abstract
objectivesIn preparation for a pediatric randomized controlled trial on thromboprophylaxis, we determined the frequency of catheter-related thrombosis in children. We also systematically reviewed the pediatric trials on thromboprophylaxis to evaluate its efficacy and to identify possible pitfalls in the conduct of these trials. PATIENTS/
methodsWe searched MEDLINE, EMBASE, Web of Science and the Cochrane Central Register for Controlled Trials for articles published until December 2013. We included cohort studies and trials on patients aged 0-18 years with central venous catheters who underwent active surveillance for thrombosis with radiologic imaging. We estimated the pooled frequency of thrombosis and the pooled risk ratio (RR) with thromboprophylaxis by using a random effects model.
resultsFrom 2651 articles identified, we analyzed 37 articles with 3128 patients. The pooled frequency of thrombosis was 0.20 (95% confidence interval [CI] 0.16-0.24). In 10 trials, we did not find evidence that heparin-bonded catheters (RR 0.34; 95%CI 0.01-7.68), unfractionated heparin (RR 0.93; 95% CI 0.57-1.51), low molecular weight heparin (RR 1.13; 95% CI 0.51-2.50), warfarin (RR 0.85; 95%CI 0.34-2.17), antithrombin concentrate (RR 0.76; 95% CI 0.38-1.55) or nitroglycerin (RR 1.53; 95%CI 0.57-4.10) reduced the risk of thrombosis. Most of the trials were either not powered for thrombosis or were powered to detect large, probably unachievable, reductions in thrombosis. Missing data on thrombosis also limited these trials.
conclusionsCatheter-related thrombosis is common in children. An adequately powered multicenter trial that can detect a modest, clinically significant reduction in thrombosis is critically needed. Missing outcome data should be minimized in this trial.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.